ArticleBritish journal of cancer2005
The use of Raman spectroscopy to differentiate between different prostatic adenocarcinoma cell lines.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04040673 (Evaluation of the Role of Vibrational Spectroscopy in the Diagnosis of Premalignant and Malignant Disease of the Thyroid RAFTER), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Role of Vibrational Spectroscopy in the Diagnosis of Premalignant and Malignant Disease of the Thyroid RAFTER (RAman For Thyroid cancER)
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Raman spectroscopy in the diagnosis of bladder cancer: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Tracking Metabolic Responses to Citalopram in Colon Cells with Raman Spectroscopy.Analytical chemistry · 2026Article
- Intraductal carcinoma of the prostate: A comprehensive literature review focused on grading challenges and controversies.Histology and histopathology · 2025Review
- Raman micro-spectroscopy reveals the metabolic alterations in primary prostate tumor tissues of patients with metastases.Journal of translational medicine · 2025Article
- Unsupervised self-organising map classification of Raman spectra from prostate cell lines uncovers substratified prostate cancer disease states.Scientific reports · 2025Article
- Non-invasive early-stage cancer detection: current methods and future perspectives.Clinical and experimental medicine · 2024Review
- Raman spectroscopy reveals oxidative stress-induced metabolic vulnerabilities in early-stage AR-negative prostate-cancer versus normal-prostate cell lines.Scientific reports · 2024Article
- Advancements and prospects of Raman spectroscopy in urological tumors: a bibliometric analysis.Lasers in medical science · 2023Review
- Evaluation of the Cytotoxic Effect of PdInternational journal of molecular sciences · 2023Article
- Building an ensemble learning model for gastric cancer cell line classification via rapid raman spectroscopy.Computational and structural biotechnology journal · 2023Article
- [Application of Raman-based technologies in the detection of urological tumors].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning.Biosensors & bioelectronics · 2022Article
- Label-free discrimination of tumorigenesis stages using in vitro prostate cancer bone metastasis model by Raman imaging.Scientific reports · 2022Article
- A Single-Cell Raman Spectroscopy Analysis of Bone Marrow Mesenchymal Stem/Stromal Cells to Identify Inter-Individual Diversity.International journal of molecular sciences · 2022Article
- Dimensional reduction based on peak fitting of Raman micro spectroscopy data improves detection of prostate cancer in tissue specimens.Journal of biomedical optics · 2021Article
- Article
- Diagnostic accuracy of Raman spectroscopy for prostate cancer: a systematic review and meta-analysis.Translational andrology and urology · 2021Article
- Evaluation of aromatic amino acids as potential biomarkers in breast cancer by Raman spectroscopy analysis.Scientific reports · 2021Article
- Detection and Classification of Multi-Type Cells by Using Confocal Raman Spectroscopy.Frontiers in chemistry · 2021Article
- Identification of intraductal carcinoma of the prostate on tissue specimens using Raman micro-spectroscopy: A diagnostic accuracy case-control study with multicohort validation.PLoS medicine · 2020Article
Corrections and comments
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raman spectroscopy (RS) is an optical technique that provides an objective method of pathological diagnosis based on the molecular composition of tissue. Studies have shown that the technique can accurately identify and grade prostatic adenocarcinoma (CaP) in vitro. This study aimed to determine whether RS was able to differentiate between CaP cell lines of varying degrees of biological aggressiveness. Raman spectra were measured from two well-differentiated, androgen-sensitive cell lines (LNCaP and PCa 2b) and two poorly differentiated, androgen-insensitive cell lines (DU145 and PC 3). Principal component analysis was used to study the molecular differences that exist between cell lines and, in conjunction with linear discriminant analysis, was applied to 200 spectra to construct a diagnostic algorithm capable of differentiating between the different cell lines. The algorithm was able to identify the cell line of each individual cell with an overall sensitivity of 98% and a specificity of 99%. The results further demonstrate the ability of RS to differentiate between CaP samples of varying biological aggressiveness. RS shows promise for application in the diagnosis and grading of CaP in clinical practise as well as providing molecular information on CaP samples in a research setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.