ArticleThe Journal of general physiology2005
The limit of photoreceptor sensitivity: molecular mechanisms of dark noise in retinal cones.
Article in The Journal of general physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Dark continuous noise from visual pigment as a major mechanism underlying rod-cone difference in light sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Analysis of dim-light responses in rod and cone photoreceptors with altered calcium kinetics.Journal of mathematical biology · 2023Article
- Article
- Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes.Current biology : CB · 2020Article
- Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction.PloS one · 2019Article
- A novel mechanism of cone photoreceptor adaptation.PLoS biology · 2017Article
- Biophotons Contribute to Retinal Dark Noise.Neuroscience bulletin · 2016Article
- How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Detection of single photons by toad and mouse rods.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Origin and effect of phototransduction noise in primate cone photoreceptors.Nature neuroscience · 2013Article
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Functional significance of the taper of vertebrate cone photoreceptors.The Journal of general physiology · 2012Article
- Speed, adaptation, and stability of the response to light in cone photoreceptors: the functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels.The Journal of general physiology · 2012Article
- Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.The Journal of general physiology · 2010Article
- Binding by asynchrony: the neuronal phase code.Frontiers in neuroscience · 2010Article
- Inhibition of nitric oxide synthase desensitizes retinal ganglion cells to light by diminishing their excitatory synaptic currents under light adaptation.Vision research · 2009Article
- Quantal noise from human red cone pigment.Nature neuroscience · 2008Article
- The dynamics of phosphodiesterase activation in rods and cones.Biophysical journal · 2008Article
- Chromophore switch from 11-cis-dehydroretinal (A2) to 11-cis-retinal (A1) decreases dark noise in salamander red rods.The Journal of physiology · 2007Article
- Physiological properties of rod photoreceptor cells in green-sensitive cone pigment knock-in mice.The Journal of general physiology · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Detection threshold in cone photoreceptors requires the simultaneous absorption of several photons because single photon photocurrent is small in amplitude and does not exceed intrinsic fluctuations in the outer segment dark current (dark noise). To understand the mechanisms that limit light sensitivity, we characterized the molecular origin of dark noise in intact, isolated bass single cones. Dark noise is caused by continuous fluctuations in the cytoplasmic concentrations of both cGMP and Ca(2+) that arise from the activity in darkness of both guanylate cyclase (GC), the enzyme that synthesizes cGMP, and phosphodiesterase (PDE), the enzyme that hydrolyzes it. In cones loaded with high concentration Ca(2+) buffering agents, we demonstrate that variation in cGMP levels arise from fluctuations in the mean PDE enzymatic activity. The rates of PDE activation and inactivation determine the quantitative characteristics of the dark noise power density spectrum. We developed a mathematical model based on the dynamics of PDE activity that accurately predicts this power spectrum. Analysis of the experimental data with the theoretical model allows us to determine the rates of PDE activation and deactivation in the intact photoreceptor. In fish cones, the mean lifetime of active PDE at room temperature is approximately 55 ms. In nonmammalian rods, in contrast, active PDE lifetime is approximately 555 ms. This remarkable difference helps explain why cones are noisier than rods and why cone photocurrents are smaller in peak amplitude and faster in time course than those in rods. Both these features make cones less light sensitive than rods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.