ArticleThe Journal of cell biology2005
Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 127 citations in OpenAlex.
- Towards the Establishment of a Sea Urchin Sperm Biobank: Key Challenges and Opportunities for the Conservation and Sustainable Aquaculture ofAnimals : an open access journal from MDPI · 2026Review
- Analysis of CaFrontiers in cell and developmental biology · 2024Article
- Calaxin is required for asymmetric bend initiation and propagation in sperm flagella.Frontiers in cell and developmental biology · 2023Article
- Sperm ion channels and transporters in male fertility and infertility.Nature reviews. Urology · 2021Review
- Modelling Motility: The Mathematics of Spermatozoa.Frontiers in cell and developmental biology · 2021Review
- Differences and Similarities: The Richness of Comparative Sperm Physiology.Physiology (Bethesda, Md.) · 2020Review
- Article
- Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm.PLoS computational biology · 2020Article
- Article
- Automated identification of flagella from videomicroscopy via the medial axis transform.Scientific reports · 2019Article
- Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a†.Biology of reproduction · 2019Article
- The role of alkalinization-induced Ca2+ influx in sperm motility activation of a viviparous fish Redtail Splitfin (Xenotoca eiseni).Biology of reproduction · 2018Article
- Calaxin establishes basal body orientation and coordinates movement of monocilia in sea urchin embryos.Scientific reports · 2017Article
- Sperm Sensory Signaling.Cold Spring Harbor perspectives in biology · 2017Review
- Network model predicts that CatSper is the main CaScientific reports · 2017Article
- Phototaxis and chemotaxis of brown algal swarmers.Journal of plant research · 2017Review
- Extracellular Ca2+ Is Required for Fertilization in the African Clawed Frog, Xenopus laevis.PloS one · 2017Article
- Article
- Sperm navigation along helical paths in 3D chemoattractant landscapes.Nature communications · 2015Article
- The CatSper channel controls chemosensation in sea urchin sperm.The EMBO journal · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Eggs of many marine and mammalian species attract sperm by releasing chemoattractants that modify the bending properties of flagella to redirect sperm paths toward the egg. This process, called chemotaxis, is dependent on extracellular Ca(2+). We used stroboscopic fluorescence imaging to measure intracellular Ca(2+) concentration ([Ca(2+)]i) in the flagella of swimming sea urchin sperm. Uncaging of cyclic GMP induced Ca(2+) entry via at least two distinct pathways, and we identified a nimodipine-sensitive pathway, compartmentalized in the flagella, as a key regulator of flagellar bending and directed motility changes. We found that, contrary to current models, the degree of flagellar bending does not vary in proportion to the overall [Ca(2+)]i. Instead we propose a new model whereby flagella bending is increased by Ca(2+) flux through the nimodipine-sensitive pathway, and is unaffected by [Ca(2+)]i increases through alternative pathways.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.