ArticleThe Journal of experimental medicine2005
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed.
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.Nature · 2018Article
- A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell ActivationFrontiers in immunology · 2018Article
- The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging.Methods (San Diego, Calif.) · 2017Review
- Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen.International journal of immunopathology and pharmacology · 2017Article
- Mathematics in modern immunology.Interface focus · 2016Review
- Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis.Frontiers in immunology · 2016Review
- Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs.Frontiers in immunology · 2016Review
- Plant-made oral vaccines against human infectious diseases-Are we there yet?Plant biotechnology journal · 2015Review
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- Article
- Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits.Cellular immunology · 2015Article
- Cellular imaging in rheumatic diseases.Nature reviews. Rheumatology · 2015Review
- Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.PLoS neglected tropical diseases · 2015Article
- An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Peripheral tolerance and autoimmunity: lessons from in vivo imaging.Immunologic research · 2013Review
- Functional immunoimaging: the revolution continues.Nature reviews. Immunology · 2012Review
- Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy.Journal of leukocyte biology · 2012Article
- Two-photon imaging of microbial immunity in living tissues.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012Review
- Oral tolerance to food protein.Mucosal immunology · 2012Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo. We have therefore tracked such cells in real time, in situ during the induction of oral priming versus oral tolerance. There were marked contrasts with respect to rate and type of movement and clustering between naive T cells and those exposed to antigen in immunogenic or tolerogenic forms. However, the major difference when comparing tolerized and primed T cells was that the latter formed larger and longer-lived clusters within mucosal and peripheral lymph nodes. This is the first comparison of the behavior of antigen-specific CD4+ T cells in situ in mucosal and systemic lymphoid tissues during the induction of priming versus tolerance in a physiologically relevant model in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.