ArticleProceedings of the National Academy of Sciences of the United States of America2005
A chemical waveform synthesizer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Acoustofluidic chemical waveform generator and switch.Analytical chemistry · 2014Article
- Probing enzymatic activity inside single cells.Analytical chemistry · 2013Article
- Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Linear conversion of pressure into concentration, rapid switching of concentration, and generation of linear ramps of concentration in a microfluidic device.Biomicrofluidics · 2012Article
- Controlling mass transport in microfluidic devices.Annual review of analytical chemistry (Palo Alto, Calif.) · 2011Review
- Phase-locked signals elucidate circuit architecture of an oscillatory pathway.PLoS computational biology · 2010Article
- Microfluidic multi-analyte gradient generator.Analytical and bioanalytical chemistry · 2010Article
- Microfluidic system for generation of sinusoidal glucose waveforms for entrainment of islets of Langerhans.Analytical chemistry · 2010Article
- Microfluidic devices for measuring gene network dynamics in single cells.Nature reviews. Genetics · 2009Review
- Direct access and control of the intracellular solution environment in single cells.Analytical chemistry · 2009Article
- The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks.Accounts of chemical research · 2008Article
- Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Algorithms and methods were developed to synthesize complex chemical waveforms in open volumes by using a scanning-probe microfluidic platform. Time-dependent variations and oscillations of one or several chemical species around the scanning probe, such as formation of sine waves, damped oscillations, and generation of more complex patterns, are demonstrated. Furthermore, we show that intricate bursting and chaotic calcium oscillations found in biological microdomains can be reproduced and that a biological cell can be used as a probe to study receptor functionalities as a function of exposure to time-dependent variations of receptor activators and inhibitors. Thus, the method allows for studies of biologically important oscillatory reactions. More generally, the system allows for detailed studies of complex time-varying chemical and physical phenomena in solution or at solution/surface interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.