ArticleImmunology1992
Properties of human thymic B cells.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Whole-Thorax Irradiation Induces Persistent T Cell Clonal Dysregulation in Pediatric Rhesus Macaques.Radiation research · 2025Article
- Thymic B cells in aging and autoimmune disease.Frontiers in immunology · 2025Review
- Early-life homeostatic differentiation of thymus-resident B cells into memory B cells.Frontiers in immunology · 2025Article
- B cell deficiency in thymoma tissues of Good's syndrome patients.Discover oncology · 2024Article
- Clones reactive to apoptotic cells and specific chemical adducts are prevalent among human thymic B cells.Frontiers in immunology · 2024Article
- Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity.iScience · 2023Article
- Thymus Gland: A Double Edge Sword for Coronaviruses.Vaccines · 2021Review
- The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity.Frontiers in immunology · 2021Review
- Thymic B Cells as a New Player in the Type 1 Diabetes Response.Frontiers in immunology · 2021Review
- Coexpression of CD5 and CD43 predicts worse prognosis in diffuse large B-cell lymphoma.Cancer medicine · 2018Article
- Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development.Frontiers in immunology · 2018Article
- Evaluation of a panel of antibodies for the immunohistochemical identification of immune cells in paraffin-embedded lymphoid tissues of new- and old-world camelids.Veterinary immunology and immunopathology · 2017Article
- The human thymus perivascular space is a functional niche for viral-specific plasma cells.Science immunology · 2016Article
- Transfer of maternal immunity to newborns of diabetic mothers.Clinical & developmental immunology · 2012Article
- Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive chemicals.Environmental health perspectives · 2011Article
- Fetal lambs are depleted of IgM+ cells following a single injection of an anti-IgM antibody early in gestation.Immunology · 1996Article
- Thymic B cells of pig fetuses and germ-free pigs spontaneously produce IgM, IgG and IgA: detection by ELISPOT method.Immunology · 1996Article
- Polyclonal immunoglobulin response of thymic, hepatic and splenic lymphocytes from fetal, germ-free and conventionally reared pigs to different B-cell activators.Folia microbiologica · 1995Article
- Involution of the rat thymus in experimentally induced hypothyroidism.Cell and tissue research · 1994Article
- A novel internal antigen which distinguishes germinal centre cells from other B-cell types.Immunology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cells, distinct from those seen in myasthenia gravis, are present in normal human thymic medulla, concentrated around the Hassall's corpuscles. We have shown that they constitute 33 +/- 4.8% of the total cells in the thymic medulla. In tissue sections they were often seen to have rosettes of thymocytes around them, a relationship which was maintained when the cells were isolated from the thymus. Thymic B cells expressed cytoplasmic immunoglobulins IgD, IgM and IgG but only rarely IgA. Unlike murine thymic B cells, human thymic B cells were CD5-. Freshly isolated thymic B cells were activated cells, but they rapidly became quiescent and died in culture over a 10-day period unless stimulated with mitogens. Thymic B cells responded to polyclonal B-cell activators SAC and TPA and when stimulated, maintained their relationship with thymocytes. Electron microscopic studies showed that two morphologically different thymocyte populations associated with the B cells. The plasma membranes of larger thymocytes were juxtaposed to the B-cell membrane, but smaller thymocytes with darker cytoplasm were associated with the B cells via cytoplasmic strands. Studies in mice have suggested that B cells are involved in thymic negative selection. The close association between activated B cells and thymocytes observed in this study supports this hypothesis.
Indexed as
Identifiers
1592434PMC1384836W199676798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.