ArticleThe British journal of ophthalmology2005
Human retinal microglia express candidate receptors for HIV-1 infection.
Article in The British journal of ophthalmology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Human Immunodeficiency Virus and Uveitis.Viruses · 2023Review
- Isolation and Characterization of Primary Retinal Microglia From the Human Post-mortem Eyes for Future Studies of Ocular Diseases.Frontiers in cellular neuroscience · 2021Article
- Ccl5 Mediates Proper Wiring of Feedforward and Lateral Inhibition Pathways in the Inner Retina.Frontiers in neuroscience · 2018Article
- Constitutive and Stress-induced Expression of CCL5 Machinery in Rodent Retina.Journal of clinical & cellular immunology · 2017Article
- Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].Scientific reports · 2015Article
- HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.Laboratory investigation; a journal of technical methods and pathology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsMicroglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may damage neural tissue via the release of neurotoxins. All cells bearing CD4 molecules and co-receptors (members of the chemokine receptor and Fcgamma receptor families) are potential targets for the human immunodeficiency virus (HIV). In this study, retinal microglia (in vitro and in situ) were investigated for the expression of candidate HIV-1 binding receptors.
methodsCultured human retinal microglia and frozen sections of human retinas were used. Immunohistochemistry was used to investigate expression of cell surface receptors necessary for HIV-1 infection: CD4, CC chemokine receptor 5 (CCR5), and Fcgamma receptors.
resultsHuman retinal microglia expressed detectable levels of CD4, CD16, CD64, and CCR5 in vitro and Fcgamma receptor I (CD64) in situ.
conclusionsHuman retinal microglia express several candidate receptors required for viral binding and as such may be a potential reservoir for HIV-1 infection.
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