ArticleJournal of medical ethics2005
Ethical concerns regarding guidelines for the conduct of clinical research on children.
Article in Journal of medical ethics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Using Radial Shock Wave Therapy to Control Cerebral Palsy-Related Dysfunctions: A Randomized Controlled Trial.International journal of general medicine · 2025Trial
- Using a Respectful Approach to Child-centred Healthcare (ReACH) in a paediatric clinical trial: A feasibility study.PloS one · 2020Trial
- Trial
- Trial
- Ethical key issues and fundamental rights in paediatric research.European journal of clinical pharmacology · 2011Trial
- Effect of Using VR Game-Based Training to Correct Lumbar Curve in Chronic Low Back Pain Patients: Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Non-static framework for understanding adaptive designs: an ethical justification in paediatric trials.Journal of medical ethics · 2022Article
- Ethics of randomized trials in pediatric surgery.Pediatric surgery international · 2020Review
- Low dissemination rates, non-transparency of trial premature cessation and late registration in child mental health: observational study of registered interventional trials.European child & adolescent psychiatry · 2020Observational
- Parental Perceptions About Informed Consent/Assent in Pediatric Research in Jordan.Journal of empirical research on human research ethics : JERHRE · 2017Article
- Key ethical issues in pediatric research: islamic perspective, Iranian experience.Iranian journal of pediatrics · 2012Article
- Paediatric palliative care research in Canada: Development and progress of a new emerging team.Paediatrics & child health · 2008Article
- Ethics in studies on children and environmental health.Journal of medical ethics · 2007Review
- British and Canadian views on the ethics of paediatric clinical trials.European journal of clinical pharmacology · 2007Article
- Valid consent for genomic epidemiology in developing countries.PLoS medicine · 2007Review
- Prediction of total body water in infants and children.Archives of disease in childhood · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article we examine ethical aspects of the involvement of children in clinical research, specifically those who are incapable of giving informed consent to participate. The topic is, of course, not a new one in medical ethics but there are some tensions in current guidelines that, in our view, need to be made explicit and which need to be responded to by the relevant official bodies. In particular, we focus on tensions between the World Medical Association Declaration of Helsinki, and the guidance offered by the British Medical Association, the Royal College of Paediatrics and Child Health (formerly the British Paediatric Association), and the Council for International Organizations of Medical Sciences. We conclude with a call for these organisations to make their guidance explicit in relation to the World Medical Association Declaration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.