ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2005
Polarized expression of CD74 by gastric epithelial cells.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- High expression of CD74 is associated with poor prognosis and tumor immune infiltration in Acute Myeloid Leukemia.Discover oncology · 2026Article
- Review
- A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models.Experimental hematology & oncology · 2023Article
- Vulture Genomes Reveal Molecular Adaptations Underlying Obligate Scavenging and Low Levels of Genetic Diversity.Molecular biology and evolution · 2021Article
- Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion.Current topics in microbiology and immunology · 2019Review
- Macrophage Migration Inhibitory Factor Receptor, CD74, is Overexpressed in Human and Baboon ( Papio Anubis) Endometriotic Lesions and Modulates Endometriotic Epithelial Cell Survival and Interleukin 8 Expression.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Role of macrophage migration inhibitory factor (MIF) in pollen-induced allergic conjunctivitis and pollen dermatitis in mice.PloS one · 2015Article
- Effect of Helicobacter pylori on gastric epithelial cells.World journal of gastroenterology · 2014Review
- Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Enhanced expression of CD74 in gastrointestinal cancers and benign tissues.International journal of clinical and experimental pathology · 2010Article
- CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.World journal of gastroenterology · 2009Review
- Macrophage CD74 contributes to MIF-induced pulmonary inflammation.Respiratory research · 2009Article
- Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.Journal of clinical biochemistry and nutrition · 2008Article
- H pylori and host interactions that influence pathogenesis.World journal of gastroenterology · 2006Review
- CD44 and CD74: The promising candidates for molecular targeted therapy in oral squamous cell carcinoma.Dental research journalArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
CD74 is known as the major histocompatibility complex (MHC) class II-associated invariant chain (Ii) that regulates the cell biology and functions of MHC class II molecules. Class II MHC and Ii expression was believed to be restricted to classical antigen-presenting cells (APC); however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules. Given the importance of Ii in the biology of class II MHC, we sought to examine the expression of Ii by gastric epithelial cells (GEC) to determine whether class II MHC molecules in these nonconventional APC cells were under the control of Ii and to further support the role that these cells may play in local immune and inflammatory responses during Helicobacter pylori infection. Thus we examined the expression of Ii on GEC from human biopsy samples and then confirmed this observation using independent methods on several GEC lines. The mRNA for Ii was detected by RT-PCR, and the various protein isoforms were also detected. Interestingly, these cells have a high level expression of surface Ii, which is polarized to the apical surface. These studies are the first to demonstrate the constitutive expression of Ii by human GEC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.