ArticlePlant physiology2005
The Arabidopsis transcription factor MYB12 is a flavonol-specific regulator of phenylpropanoid biosynthesis.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 380 papers.
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380 citing papers in PubMed, 835 citations in OpenAlex.
- Transcriptome-wide identification of R2R3-MYB protein family and functional analysis of CpMYB44 in Cyclocarya paliurus during Colletotrichum fructicola infection.Pest management science · 2026Article
- Overview of molecular mechanisms underlying stress responses; signaling pathways and secondary metabolite synthesis in plants.Plant molecular biology · 2026Review
- Evolutionary and functional divergence of MYB regulatory networks in flavonoid biosynthesis across Poaceae, non-Poaceae monocots, and eudicot horticultural plants.Horticulture research · 2026Review
- Integration of Transcriptomics and Metabolomics Reveals Organ-Specific Biosynthesis and Accumulation of Pharmacologically Active Flavonoids inPlants (Basel, Switzerland) · 2026Article
- MYB transcription factors in plant cold stress adaptation: integrating phylogeny, signaling networks, and metabolic regulation.Physiology and molecular biology of plants : an international journal of functional plant biology · 2026Review
- Analysis of the Function and Regulatory Mechanisms of thePlants (Basel, Switzerland) · 2026Article
- Screening and functional identification of CtMYB2 as a positive regulator of flavonoid biosynthesis in safflower (Carthamus tinctorius L.).BMC plant biology · 2026Article
- Genetic and Transcriptomic Analyses of the Purple Coloration Trait in the Inbred Line 7A01 ofPlants (Basel, Switzerland) · 2026Article
- Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root.The Plant cell · 2026Article
- The RcMYB21 transcription factor activates flavonol biosynthesis by targeting RcFLS in Chinese raspberry.BMC plant biology · 2026Article
- Genome-Wide Study of MYB Transcription Factors in Maize and Their Essential Roles in Male Fertility and Other Biological Processes.International journal of molecular sciences · 2026Article
- Functional divergence of cshalcone synthase genes RcCHS in regulating anthocyanin biosynthesis and stress responses in Rosa chinensis.Plant cell reports · 2026Article
- Multiple transcription factors and genes jointly regulate the light-dependent flavonoid biosynthesis mechanism of stem color in Hydrangea macrophylla.BMC plant biology · 2026Article
- miR828 positively regulates proanthocyanidin accumulation in sainfoin (Onobrychis viciifolia).BMC plant biology · 2026Article
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- R2R3 MYB Transcription Factors Involved in Flower Petal Pigmentation via Regulating Anthocyanin Synthesis in Rhododendron simsii.Molecular biotechnology · 2026Article
- Mechanisms of acclimation regulation and stress response to UV-B inFrontiers in plant science · 2026Article
- Heterologous expression of the honeysuckle R2R3-MYB transcription factor LjMYB106 enhances phenylpropanoid and flavonoid metabolism inFrontiers in plant science · 2026Article
- Integrated transcriptome and metabolome analyses uncover stage-specific dynamic regulatory networks during sesame floral development.Frontiers in plant science · 2026Article
320 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comprehensive functional data on plant R2R3-MYB transcription factors is still scarce compared to the manifold of their occurrence. Here, we identified the Arabidopsis (Arabidopsis thaliana) R2R3-MYB transcription factor MYB12 as a flavonol-specific activator of flavonoid biosynthesis. Transient expression in Arabidopsis protoplasts revealed a high degree of functional similarity between MYB12 and the structurally closely related factor P from maize (Zea mays). Both displayed similar target gene specificity, and both activated target gene promoters only in the presence of a functional MYB recognition element. The genes encoding the flavonoid biosynthesis enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, and flavonol synthase were identified as target genes. Hence, our observations further add to the general notion of a close relationship between structure and function of R2R3-MYB factors. High-performance liquid chromatography analyses of myb12 mutant plants and MYB12 overexpression plants demonstrate a tight linkage between the expression level of functional MYB12 and the flavonol content of young seedlings. Quantitative real time reverse transcription-PCR using these mutant plants showed MYB12 to be a transcriptional regulator of CHALCONE SYNTHASE and FLAVONOL SYNTHASE in planta, the gene products of which are indispensable for the biosynthesis of flavonols.
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