ArticleBrain, behavior, and immunity2005
RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.
Article in Brain, behavior, and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Effect of physical training on airway inflammation in animal models of asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.Science translational medicine · 2015Trial
- REDD1 deletion and treadmill running increase liver hepcidin and gluconeogenic enzymes in male mice.Journal of nutritional science · 2023Article
- Trabecular Bone Microarchitecture Improvement Is Associated With Skeletal Nerve Increase Following Aerobic Exercise Training in Middle-Aged Mice.Frontiers in physiology · 2021Article
- Consensus transcriptional regulatory networks of coronavirus-infected human cells.Scientific data · 2020Article
- Consensus transcriptional regulatory networks of coronavirus-infected human cells.bioRxiv : the preprint server for biology · 2020Article
- Defining a role for exercise training in the management of asthma.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets.Frontiers in aging neuroscience · 2019Article
- REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.American journal of physiology. Endocrinology and metabolism · 2017Article
- Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise.Pediatric research · 2017Article
- Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α.The Journal of international medical research · 2017Article
- Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.Biological psychiatry · 2013Article
- Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice.American journal of respiratory cell and molecular biology · 2011Article
- Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.American journal of respiratory cell and molecular biology · 2010Article
- Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model.Brain, behavior, and immunity · 2010Article
- Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma model.American journal of respiratory cell and molecular biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In an ovalbumin (OVA)-driven murine model of allergic pulmonary inflammation, we have shown previously that moderate-intensity aerobic exercise training attenuates inflammatory responses, disease progression, and NF-kappaB activation within the sensitized lung. Glucocorticoids (GCs), potent anti-inflammatory agents, have been shown to alter transcriptional events that are important in asthmatic pathogenesis, such as NF-kappaB activation. Notably, exercise training can alter the production and signaling capacity of endogenous GCs. Because GCs exert their anti-inflammatory effects through binding to intracellular glucocorticoid receptors (GRs), we examined the role of the GR in facilitating the anti-inflammatory effects of exercise. Results show that, in exercised OVA-sensitized mice, treatment with the GR antagonist RU486 blocked the exercise-induced reductions in cellular infiltration of the airways (p < .05), KC and soluble VCAM-1 protein levels in the bronchoalveloar lavage fluid (p < .05), and NF-kappaB translocation and DNA binding within the lung to levels similar to those observed in sedentary OVA-sensitized mice. Importantly, RU486 treatment also blocked exercise-induced increases in GR nuclear translocation to the levels seen in sensitized control mice. Together, these results suggest that GR nuclear translocation and NF-kappaB activation play roles in mediating the anti-inflammatory effects of exercise in allergen-mediated lung pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.