ArticleRetrovirology2005
APOBEC3G & HTLV-1: inhibition without deamination.
Article in Retrovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Human DNA tumor viruses evade uracil-mediated antiviral immunity.PLoS pathogens · 2023Article
- Review
- Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity.Journal of virology · 2018Article
- Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire.Virology journal · 2016Review
- APOBECs and virus restriction.Virology · 2015Review
- Insights into the motif preference of APOBEC3 enzymes.PloS one · 2014Article
- Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.Structure (London, England : 1993) · 2013Article
- Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine.HIV/AIDS (Auckland, N.Z.) · 2013Article
- Host restriction factors in retroviral infection: promises in virus-host interaction.Retrovirology · 2012Review
- Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution.Virology · 2011Article
- HIV-1 modulates the tRNA pool to improve translation efficiency.Molecular biology and evolution · 2011Article
- Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors.Microbiology and molecular biology reviews : MMBR · 2009Review
- Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells.Journal of virology · 2009Article
- Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.Journal of virology · 2008Article
- Article
- Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene.Nucleic acids research · 2007Article
- The cell biology of HIV-1 and other retroviruses.Retrovirology · 2006Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines. Inhibition of HIV-1 replication is thought to be the result of APOBEC3G-induced hypermutation of the viral genome that occurs early during reverse transcription. Against this backdrop is a new report from the Uchiyama laboratory that proposes deaminase-independent restriction of HTLV-1 by APOBEC3G (Sasada et al. Retrovirology 2005, 2:32). These findings combined with recent reports of deaminase-independent inhibition of Hepatitis B virus as well as HIV-1 suggest that cytidine deaminase activity and antiviral activity may be separable functional properties of APOBEC3G.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.