ArticleJournal of human hypertension2005
Persistence and discontinuation patterns of antihypertensive therapy among newly treated patients: a population-based study.
Article in Journal of human hypertension, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Sex differences in the adherence of antihypertensive drugs: a systematic review with meta-analyses.BMJ open · 2020Pooled it
- Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information.Journal of general internal medicine · 2012Pooled it
- Trial
- Simplified Approach to Managing Newly Diagnosed Patients with Mild-to-Moderate Hypertension in Routine Clinical Practice.Advances in therapy · 2025Observational
- Personalized hypertension treatment recommendations by a data-driven model.BMC medical informatics and decision making · 2023Article
- Non-persistence to antihypertensive drug therapy in Lithuania.European journal of clinical pharmacology · 2022Article
- Article
- Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study.British journal of clinical pharmacology · 2018Article
- Clinical, Socioeconomic, and Psychosocial Factors Associated with Blood Pressure Control and Adherence: Results from a Multidisciplinary Cardiovascular National Program Providing Universal Coverage in a Developing Country.International journal of hypertension · 2018Article
- Treatment adherence among adult hypertensive patients: a cross-sectional retrospective study in primary care in Romania.Patient preference and adherence · 2018Article
- The benefit of angiotensin AT1 receptor blockers for early treatment of hypertensive patients.Internal and emergency medicine · 2017Review
- Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries.AIDS (London, England) · 2017Article
- Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD).Medicine · 2016Observational
- Achieving Adherence After First-Line Antihypertensive Treatment: Should Fixed-Dose Combinations Receive Priority?Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Persistence and compliance with newly initiated antihypertensive drug treatment in patients with chronic kidney disease.Patient preference and adherence · 2016Article
- Quality of Life in Treatment-Resistant Hypertension.Current hypertension reports · 2015Review
- Antihypertensive agents acting on the renin-angiotensin system and the risk of sepsis.British journal of clinical pharmacology · 2014Article
- Antihypertensive drug treatment changes in the general population: the CoLaus study.BMC pharmacology & toxicology · 2014Article
- Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: a five-year cohort study.International journal of cardiology · 2013Observational
- Choice of initial antihypertensive drugs and persistence of drug use--a 4-year follow-up of 78,453 incident users.European journal of clinical pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective was to assess persistence with antihypertensive therapy (AHT) and discontinuation patterns in patients newly dispensed different antihypertensive drug classes in a natural Canadian population-based setting. Hypertensive patients initiating AHT monotherapy were included in this 3-year retrospective cohort study (N=21 326) using the Saskatchewan health-care databases. Persistence was defined as consistently refilling a new prescription for AHT within 90 days of a previous dispensing. New courses of AHT were also documented in nonpersistent patients. Kaplan-Meier and Cox regression analyses were used to compare persistence and new courses of therapy across initial drugs. Compared to the newer angiotensin II antagonists (AIIAs), the likelihood of discontinuing therapy over the 39-month study period was significantly higher for angiotensin-converting enzymes inhibitors (HR=1.29; 95% CI=1.16-1.43), calcium channel blockers (HR=1.42; 95% CI=1.27-1.60), beta blockers (HR=1.62; 95% CI=1.45-1.80) and diuretics (HR=1.92; 95% CI=1.73-2.14). In the year following treatment discontinuation, between 54 and 75% of patients initiated a second course of treatment. Patients initiated on an AIIA had a significantly higher likelihood of starting a new course of therapy after a first treatment discontinuation, compared to all other agents. In conclusion, hypertensive patients initiated on an AIIA not only had greater persistence to AHT but were also more likely to initiate a new course of AHT after discontinuation than those initiating treatment with other agents. Further studies are required that relate intermittent treatment behaviours to health outcomes and costs in hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.