ArticleJournal of virology2005
The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Morphology-dependent entry kinetics and spread of influenza A virus.The EMBO journal · 2025Article
- Article
- Cholesterol and M2 Rendezvous in Budding and Scission of Influenza A Virus.Sub-cellular biochemistry · 2023Article
- Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.PLoS pathogens · 2022Article
- Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer.PLoS biology · 2020Article
- ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes.Cell reports · 2018Article
- Article
- Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication.Scientific reports · 2016Article
- Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study.Influenza and other respiratory viruses · 2016Article
- hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.Scientific reports · 2016Article
- An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.Journal of virology · 2014Article
- Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.PloS one · 2014Article
- Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein.Journal of virology · 2013Article
- Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.PLoS pathogens · 2013Article
- A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication.Journal of virology · 2012Article
- Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.The Journal of cell biology · 2012Article
- Budding capability of the influenza virus neuraminidase can be modulated by tetherin.Journal of virology · 2011Article
- Human Staufen1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus multiplication.Journal of virology · 2010Article
- Influenza virus morphogenesis and budding.Virus research · 2009Review
- Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.Cell host & microbe · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs into virus particles were similar to those of wild-type virus. We propose that a threshold amount of M1 protein is needed for the assembly of viral components into an infectious particle and that budding is delayed in Mmut virus-infected cells until sufficient levels of M1 protein accumulate at the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.