ArticleJournal of virology2005
Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Host factors in parainfluenza virus replication: from entry to innate immunity evasion.Frontiers in immunology · 2026Review
- Human parainfluenza virus 3 vaccine candidates attenuated by codon-pair deoptimization are immunogenic and protective in hamsters.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- C Proteins: Controllers of Orderly Paramyxovirus Replication and of the Innate Immune Response.Viruses · 2022Review
- Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein.Journal of virology · 2018Article
- Viral protein requirements for assembly and release of human parainfluenza virus type 3 virus-like particles.The Journal of general virology · 2016Article
- Article
- Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes.BMC immunology · 2013Article
- Article
- Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy.BMJ case reports · 2013Article
- Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways.PloS one · 2013Article
- Pathogenesis of acute respiratory illness caused by human parainfluenza viruses.Current opinion in virology · 2012Review
- Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance.Journal of virology · 2011Article
- Buying time-the immune system determinants of the incubation period to respiratory viruses.Viruses · 2010Article
- Domain within the C protein of human parainfluenza virus type 3 that regulates interferon signaling.Gene expression · 2010Article
- Article
- N-terminally truncated C protein, CNDelta25, of human parainfluenza virus type 3 is a potent inhibitor of viral replication.Virology · 2009Article
- Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.PLoS pathogens · 2009Article
- Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitro.Virus research · 2009Article
- Silencing the myotrophin gene by RNA interference leads to the regression of cardiac hypertrophy.American journal of physiology. Heart and circulatory physiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The P mRNA of the viruses belonging to the subfamily Paramyxovirinae possesses a unique property of giving rise to several accessory proteins by a process that involves the utilization of overlapping open reading frames (the C proteins) and by an "RNA-editing" mechanism (the V proteins). Although these proteins are considered accessory, numerous studies have highlighted the importance of these proteins in virus transcription and interferon signaling, including our previous observation on the role of human parainfluenza virus type 3 (HPIV 3) C protein in the transcription of viral genome (Malur et al., Virus Res. 99:199-204, 2004). In this report, we have addressed its role in interferon signaling by generating a stable cell line, L-C6, by using the lentiviral expression system which expresses HPIV 3 C protein. The L-C6 cells were efficient in abrogating both alpha and gamma interferon-induced antiviral states and demonstrated a drastic reduction in the formation of gamma-activated factor complexes in the cell extracts. Western blot analysis subsequently revealed a defect in the phosphorylation of STAT 1 in these cells. Taken together, our results indicate that HPIV 3 C protein is capable of counteracting the interferon signaling pathway by specifically inhibiting the activation of STAT 1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.