ArticleJournal of virology2005
The minor receptor group of human rhinovirus (HRV) includes HRV23 and HRV25, but the presence of a lysine in the VP1 HI loop is not sufficient for receptor binding.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 83 citations in OpenAlex.
- Infection of Immature Mice with Rhinovirus for the Study of Asthma Pathogenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma.Frontiers in allergy · 2024Review
- Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice.Mucosal immunology · 2021Article
- Rhinovirus and Cell Death.Viruses · 2021Review
- SARS-CoV-2 coinfections: Could influenza and the common cold be beneficial?Journal of medical virology · 2020Article
- Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection.Frontiers in immunology · 2020Article
- More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.Frontiers in immunology · 2020Review
- Rhinovirus Attributes that Contribute to Asthma Development.Immunology and allergy clinics of North America · 2019Review
- Review
- Article
- Human Rhinovirus Diversity and Evolution: How Strange the Change from Major to Minor.Journal of virology · 2017Article
- Immune Responses in Rhinovirus-Induced Asthma Exacerbations.Current allergy and asthma reports · 2016Review
- ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments.Journal of virology · 2016Article
- Viral entry pathways: the example of common cold viruses.Wiener medizinische Wochenschrift (1946) · 2016Review
- Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model.Scientific reports · 2016Article
- Article
- Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections.Advances in experimental medicine and biology · 2015Review
- Variation in the nuclear effects of infection by different human rhinovirus serotypes.Frontiers in microbiology · 2015Article
- Classification and evolution of human rhinoviruses.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Modeling of the human rhinovirus C capsid suggests possible causes for antiviral drug resistance.Virology · 2014Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like all 10 minor receptor group human rhinoviruses (HRVs), HRV23 and HRV25, previously classified as major group viruses, are neutralized by maltose binding protein (MBP)-V33333 (a soluble recombinant concatemer of five copies of repeat 3 of the very-low-density lipoprotein receptor fused to MBP), bind to low-density lipoprotein receptor in virus overlay blots, and replicate in intercellular adhesion molecule 1 (ICAM-1)-negative COS-7 cells. From phylogenetic analysis of capsid protein VP1-coding sequences, they are also known to cluster together with other minor group strains. Therefore, they belong to the minor group; there are now 12 minor group and 87 major group HRV serotypes. Sequence comparison of the VP1 capsid proteins of all HRVs revealed that the lysine in the HI loop, strictly conserved in the 12 minor group HRVs, is also present in 9 major group serotypes that are neutralized by soluble ICAM-1. Despite the presence of this lysine, they are not neutralized by MBP-V33333 and fail to replicate in COS-7 cells and in HeLa cells in the presence of an ICAM-1-blocking antibody. These nine serotypes are therefore "true" major group viruses.
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