ArticleWorld journal of gastroenterology2005
Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of genetic instability of short tandem repeats in hepatocellular carcinoma.Scientific reports · 2025Article
- Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report.Oncology letters · 2024Article
- PTEN Tumor-Suppressor: The Dam of Stemness in Cancer.Cancers · 2019Review
- Review
- Genetic alterations in hepatocellular carcinoma: An update.World journal of gastroenterology · 2016Review
- Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.Oncotarget · 2016Article
- Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.World journal of hepatology · 2015Review
- Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma.Journal of gastroenterology · 2013Article
- Role of E-cadherin gene in gall bladder cancer and its precursor lesions.Virchows Archiv : an international journal of pathology · 2010Article
- LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.World journal of gastroenterology · 2010Article
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.Nature cell biology · 2010Article
- Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma.World journal of gastroenterology · 2009Article
- Loss of heterozygosity on 10q23 is involved in metastatic recurrence of hepatocellular carcinoma.Cancer science · 2009Article
- Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors.BMC cancer · 2009Article
- Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma.Gut and liver · 2007Article
- Chronic hepatitis B in hepatocarcinogenesis.Postgraduate medical journal · 2006Review
- Gene expression analysis in HBV transgenic mouse liver: a model to study early events related to hepatocarcinogenesis.Molecular medicine (Cambridge, Mass.)Article
- Low Levels of Microsatellite Instability at Simple Repeated Sequences Commonly Occur in Human Hepatocellular Carcinoma.Cancer genomics & proteomicsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the features of microsatellite alterations and their association with clinicopathological characteristics of hepatocellular carcinoma (HCC).
methodsLoss of heterozygosity (LOH) and microsatellite instability (MSI) of 55 microsatellite loci were detected with PCR-based microsatellite polymorphism analyses in tumors and corresponding noncancerous liver tissues of 56 surgically resected HCCs using the MegaBACE 500 automatic DNA analysis system.
resultsLOH was found in 44 of 56 HCCs (78.6%) at one or several loci. Frequencies of LOH on 1p, 4q, 8p, 16q, and 17p were 69.6% (39/56), 71.4% (40/56), 66.1% (37/56), 66.1% (37/56), and 64.3% (36/56), respectively. MSI was found in 18 of 56 HCCs (32.1%) at one or several loci. Ten of fifty-six (17.9%) HCCs had MSI-H. Serum HBV infection, alpha-fetoprotein concentration, tumor size, cirrhosis, histological grade, tumor capsule, as well as tumor intrahepatic metastasis, might be correlated with LOH on certain chromosome regions.
conclusionFrequent microsatellite alterations exist in HCC. LOH, which represents a tumor suppressor gene pathway, plays a more important role in hepatocarcinogenesis. MSI, which represents a mismatch repair gene pathway, is a rare event during liver carcinogenesis. Furthermore, LOH on certain chromosome regions may be correlated with clinicopathological characteristics in HCC.
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