Evidence map›Paper›PMID 15917572›Full record

Trial reportAntimicrobial agents and chemotherapy2005

Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery.

Federico Pea, Ettore Ferrari, Federica Pavan, Derri Roman-Pognuz, Francesco Bandello, Mario Furlanut

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04212078 (Intracameral Levofloxacin), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04212078 phase1 / phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Intracameral Levofloxacin (0.5%) Versus Intracameral Cefuroxime (1mg/0.1ml) Effect on Corneal Endothelial Cell Count and Morphology in Uneventful Phacoemulsification

TypeinterventionalSponsorNational University of MalaysiaRan2019 to 2022Enrolled138ConditionsEndophthalmitis PostoperativeArmsLevofloxacin Ophthalmic, Cefuroxime
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Federico PeaInstitute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, P. le S. Maria della Misericordia 3, 33100 Udine, Italy. federico.pea@med.uniud.it
Ettore Ferrari
Federica Pavan
Derri Roman-Pognuz
Francesco Bandello
Mario Furlanut
University of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

Indexed as

LevofloxacinAgedAged, 80 and overAnti-Bacterial AgentsAqueous HumorCataract ExtractionEndophthalmitisEyeFemaleHumansMaleMiddle AgedOfloxacinTime FactorsAnti-Bacterial AgentsLevofloxacinOfloxacin

Identifiers

PMID15917572
PMCPMC1140509
OpenAlexW2163086653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.