Evidence map›Paper›PMID 15917552›Full record

ArticleAntimicrobial agents and chemotherapy2005

DNA in antibiotic preparations: absence of intact resistance genes.

Markus Woegerbauer, Heimo Lagler, Wolfgang Graninger, Heinz Burgmann

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Markus WoegerbauerDepartment of Infectious Diseases, Department of Internal Medicine I, University of Vienna and Birkmayer Laboratories, Department of Research and Development, Schwarzspanierstrasse 15, A-1090 Vienna, Austria. m.woegerbauer@birkmayer.com
Heimo Lagler
Wolfgang Graninger
Heinz Burgmann
University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fragments of erm(E2), otrA, and aph(6) shorter than 400 bp and producer strain-specific rRNA genes were amplified from various antibiotics. The amount of genetic material and the sizes of amplicons recovered from murine feces after oral administration of a beta-lactamase-encoding plasmid indicated substantial DNA degradation in the mammalian gastrointestinal tract. These observations imply that antibiotics are no major source for horizontal resistance gene transfer in clinical settings.

Indexed as

Drug ContaminationAnimalsAnti-Bacterial AgentsBacterial ProteinsDNA, BacterialDrug Resistance, BacterialFecesFemaleGenes, BacterialGene Transfer, HorizontalHumansMiceMice, Inbred BALB CRNA, RibosomalSpecies SpecificityAnti-Bacterial AgentsBacterial ProteinsDNA, BacterialRNA, Ribosomal

Identifiers

PMID15917552
PMCPMC1140494
OpenAlexW2161937674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.