ArticleAntimicrobial agents and chemotherapy2005
Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of noninfected rats.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Dynamic distribution of systemically administered antibiotics in orthopeadically relevant target tissues and settings.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2024Pooled it
- Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.Antimicrobial agents and chemotherapy · 2011Trial
- Prediction of higher ceftazidime-avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis.Antimicrobial agents and chemotherapy · 2025Article
- Lung microdialysis andFrontiers in veterinary science · 2024Article
- Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis.Antimicrobial agents and chemotherapy · 2018Article
- Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats.Antimicrobial agents and chemotherapy · 2017Article
- Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys.Pharmaceutical research · 2015Article
- Comparison of intrapulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and colistin after aerosol delivery and intravenous administration of CMS in critically ill patients.Antimicrobial agents and chemotherapy · 2014Article
- Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study.BMC cancer · 2010Article
- Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state.Antimicrobial agents and chemotherapy · 2008Article
- Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis.Antimicrobial agents and chemotherapy · 2008Article
- Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution.Clinical pharmacokinetics · 2008Article
- Mini-broncho-alveolar lavage: a simple and promising method for assessment of antibiotic concentration in epithelial lining fluid.Intensive care medicine · 2007Article
- Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats.Antimicrobial agents and chemotherapy · 2006Article
- Microdialysis study of imipenem distribution in the intraperitoneal fluid of rats with or without experimental peritonitis.Antimicrobial agents and chemotherapy · 2006Article
- Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration.Antimicrobial agents and chemotherapy · 2006Article
- Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis.Antimicrobial agents and chemotherapy · 2005Article
- Pharmacokinetic modeling of free amoxicillin concentrations in rat muscle extracellular fluids determined by microdialysis.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the imipenem distribution in muscle and lung interstitial fluids by microdialysis in rats and to compare the free concentrations in tissue with the free concentrations in blood. Microdialysis probes were inserted into the jugular vein, hind leg muscle, and lung. Imipenem recoveries in these three media were determined in each rat by retrodialysis by drug period before drug administration. Imipenem was infused intravenously at a dose of 120 mg . kg-1 over 30 min, and microdialysis samples were collected for 150 min. The whole study was conducted with nonhydrated rats (n=4) and hydrated rats (n=6) while the animals were under isoflurane anesthesia. The decay of free concentrations in blood, muscle, and lung with time were monoexponential; and the concentration profiles in these three media were virtually superimposed in both groups. Accordingly, the ratios of the area under the curve (AUC) for tissue (muscle or lung) to the AUC for blood were always virtually equal to 1. Compared to values previously determined with awake rats, clearance was reduced by 2 and 1.5 in nonhydrated and hydrated rats, respectively, but the volume of distribution was unchanged. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.
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