ArticleBMC microbiology2005
Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England.
Article in BMC microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 51 citations in OpenAlex.
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- Characterization of clarithromycin heteroresistance among Helicobacter pylori strains isolated from the antrum and corpus of the stomach.Folia microbiologica · 2019Article
- What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases.World journal of gastroenterology · 2015Review
- Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Prevalence of genotypes in Helicobacter pyloriisolates from patients in eastern Turkey and the association of these genotypes with clinical outcome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients.Annals of clinical microbiology and antimicrobials · 2010Article
- Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.Polish journal of microbiology · 2010Article
- Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population.Journal of gastroenterology and hepatology · 2010Article
- Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer.Journal of clinical microbiology · 2009Article
- Helicobacter urease: niche construction at the single molecule level.Journal of biosciences · 2009Article
- Determination of Helicobacter pylori virulence by analysis of the cag pathogenicity island isolated from Iranian patients.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2009Article
- Distribution of Helicobacter pylori cagA, cagE, oipA and vacA in different major ethnic groups in Tehran, Iran.Journal of gastroenterology and hepatology · 2009Article
- Helicobacter pylori vacA arrangement and related diseases: a retrospective study over a period of 15 years.Digestive diseases and sciences · 2009Article
- Involvement of the Helicobacter pylori plasticity region and cag pathogenicity island genes in the development of gastroduodenal diseases.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008Article
- Ancestral European roots of Helicobacter pylori in India.BMC genomics · 2007Article
- Helicobacter pylori genotypes identified in gastric biopsy specimens from Jordanian patients.BMC gastroenterology · 2006Article
- Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island.BMC genomics · 2006Article
- Epidemiology and pattern of antibiotic resistance in Helicobacter pylori: scenario from Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
- Antibiotic susceptibility profile of Helicobacter pylori isolated from the dyspepsia patients in Tehran, Iran.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenomic diversity of H. pylori from many different human populations is largely unknown. We compared genomes of 65 H. pylori strains from Nottingham, England. Molecular analysis was carried out to identify rearrangements within and outside the cag-pathogenicity-island (cag PAI) and DNA sequence divergence in candidate genes. Phylogenetic analysis was carried out based on various high-resolution genotyping techniques.
resultsAnalyses of virulence genes (cagT, cagE, cagA, vacA, iceA, oipA and babB) revealed that H. pylori strains from England are genetically distinct from strains obtained from other countries. The toxigenic vacA s1m1 genotype was found to be less common and the plasticity region cluster was found to be disrupted in all the isolates. English isolates showed a predominance of iceA1 alleles and a functional proinflammatory oipA gene. The English H. pylori gene pool revealed several Asian/oriental features. This included the predominance of cagA - glr (cagA right junction) motif types III and II (up to 42%), presence of vacA m1c alleles and phylogenetic affinity towards East Asian / Amerindian gene pools based on fluorescent amplified fragment length polymorphism (FAFLP) analysis and glmM sequence analysis.
conclusionOverall, our results demonstrated genetic affinities of H. pylori in England with both European and the Asian gene pools and some distinctive genetic features of virulence genes that may have evolved in this important European population.
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