ArticlePLoS medicine2005
National trends in statin use by coronary heart disease risk category.
Article in PLoS medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Cardiovascular health disparities: a systematic review of health care interventions.Medical care research and review : MCRR · 2007Pooled it
- Effect of an Automated Patient Dashboard Using Active Choice and Peer Comparison Performance Feedback to Physicians on Statin Prescribing: The PRESCRIBE Cluster Randomized Clinical Trial.JAMA network open · 2018Trial
- Targeted case finding in the prevention of cardiovascular disease: a stepped wedge cluster randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016 · on this mapTrial
- Appropriateness of cholesterol management in primary care by sex and level of cardiovascular risk.Preventive cardiology · 2009Trial
- Sex- and race/ethnic differences in short- and long-term mortality after hospitalization for incident acute myocardial infarction.American heart journal plus : cardiology research and practice · 2026Article
- Article
- Trends in Short-, Intermediate-, and Long-Term Mortality Following Hospitalization for Myocardial Infarction Among Medicare Beneficiaries, 2008 to 2018.Journal of the American Heart Association · 2023Article
- Analyzing and Improving the Utilization of Statin Drugs in Family Medicine Patients with Type II Diabetes.Journal of community hospital internal medicine perspectives · 2023Article
- Long-Term Outcomes are Similar Despite Sex Disparities in High-Intensity Statin Use in Patients With Nonobstructive Coronary Artery Disease Diagnosed Via Invasive Coronary Angiography.Journal of the American Heart Association · 2022Article
- Is race or ethnicity associated with under-utilization of statins among women in the United States: The study of women's health across the nation.Clinical cardiology · 2020Article
- Statin use in patients with non-HMGCR idiopathic inflammatory myopathies: A retrospective study.Clinical cardiology · 2020Article
- Long-term statin persistence is poor among high-risk patients with dyslipidemia: a real-world administrative claims analysis.Lipids in health and disease · 2019Article
- Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons.American heart journal · 2019Article
- Treatment gaps and potential cardiovascular risk reduction from expanded statin use in the US and England.PloS one · 2018Article
- Cardiovascular care guideline implementation in community health centers in Oregon: a mixed-methods analysis of real-world barriers and challenges.BMC health services research · 2017Article
- Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2017Article
- Effects of an evidence-based computerized virtual clinician on low-density lipoprotein and non-high-density lipoprotein cholesterol in adults without cardiovascular disease: The Interactive Cholesterol Advisory Tool.Health informatics journal · 2016Article
- Prevalence and Factors Associated With Statin Use Among a Nationally Representative Sample of US Adults: National Health and Nutrition Examination Survey, 2011-2012.Clinical cardiology · 2016Article
- Time trends in the prescription of statins for the primary prevention of cardiovascular disease in the United Kingdom: a cohort study using The Health Improvement Network primary care data.Clinical epidemiology · 2016Article
- Drivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOnly limited research tracks United States trends in the use of statins recorded during outpatient visits, particularly use by patients at moderate to high cardiovascular risk. METHODS AND
findingsData collected between 1992 and 2002 in two federally administered surveys provided national estimates of statin use among ambulatory patients, stratified by coronary heart disease risk based on risk factor counting and clinical diagnoses. Statin use grew from 47% of all lipid-lowering medications in 1992 to 87% in 2002, with atorvastatin being the leading medication in 2002. Statin use by patients with hyperlipidemia, as recorded by the number of patient visits, increased significantly from 9% of patient visits in 1992 to 49% in 2000 but then declined to 36% in 2002. Absolute increases in the rate of statin use were greatest for high-risk patients, from 4% of patient visits in 1992 to 19% in 2002. Use among moderate-risk patients increased from 2% of patient visits in 1992 to 14% in 1999 but showed no continued growth subsequently. In 2002, 1 y after the release of the Adult Treatment Panel III recommendations, treatment gaps in statin use were detected for more than 50% of outpatient visits by moderate- and high-risk patients with reported hyperlipidemia. Lower statin use was independently associated with younger patient age, female gender, African American race (versus non-Hispanic white), and non-cardiologist care.
conclusionDespite notable improvements in the past decade, clinical practice fails to institute recommended statin therapy during many ambulatory visits of patients at moderate-to-high cardiovascular risk. Innovative approaches are needed to promote appropriate, more aggressive statin use for eligible patients.
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