ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Translesion synthesis polymerases contribute to meiotic chromosome segregation and cohesin dynamics inJournal of cell science · 2020Article
- Cloning and characterization of the homoeologous genes for the Rec8-like meiotic cohesin in polyploid wheat.BMC plant biology · 2018Article
- Article
- Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis.G3 (Bethesda, Md.) · 2014Article
- Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis.Cell cycle (Georgetown, Tex.) · 2014Article
- Shugoshins function as a guardian for chromosomal stability in nuclear division.Cell cycle (Georgetown, Tex.) · 2012Review
- Meiosis in male Drosophila.Spermatogenesis · 2012Article
- Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.Genes & development · 2010Article
- Coupling meiotic chromosome axis integrity to recombination.Genes & development · 2008Article
- sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.Developmental cell · 2008Article
- Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis.The Journal of cell biology · 2008Article
- Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.Genes & development · 2007Article
- INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.Developmental cell · 2006Article
- Basic mechanism of eukaryotic chromosome segregation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In meiosis, a physical attachment, or cohesion, between the centromeres of the sister chromatids is retained until their separation at anaphase II. This cohesion is essential for ensuring accurate segregation of the sister chromatids in meiosis II and avoiding aneuploidy, a condition that can lead to prenatal lethality or birth defects. The Drosophila MEI-S332 protein localizes to centromeres when sister chromatids are attached in mitosis and meiosis, and it is required to maintain cohesion at the centromeres after cohesion along the sister chromatid arms is lost at the metaphase I/anaphase I transition. MEI-S332 is the founding member of a family of proteins that protect centromeric cohesion but whose members also affect kinetochore behaviour and spindle microtubule dynamics. We compare the Drosophila MEI-S332 family members, evaluate the role of MEI-S332 in mitosis and meiosis I, and discuss the regulation of localization of MEI-S332 to the centromere and its dissociation at anaphase. We analyse the relationship between MEI-S332 and cohesin, a protein complex that is also necessary for sister-chromatid cohesion in mitosis and meiosis. In mitosis, centromere localization of <EI-S332 is not dependent upon the cohesin complex, and cohesin retains its association with mitotic chromosomes even in the absence of MEI-S332.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.