ArticleHuman genetics2005
Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Brief psychotic episode in a patient with chromosome 2q37 microdeletion syndrome.BMJ case reports · 2017Article
- Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.Molecular neuropsychiatry · 2017Article
- Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies.The American journal of psychiatry · 2014Article
- Article
- Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees.Biological psychiatry · 2011Article
- Genetic and functional analysis of the DLG4 gene encoding the post-synaptic density protein 95 in schizophrenia.PloS one · 2010Article
- Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.Molecular psychiatry · 2010Article
- Linkage analysis of schizophrenia in African-American families.Schizophrenia research · 2009Article
- The myelin-pathogenesis puzzle in schizophrenia: a literature review.Molecular psychiatry · 2008Review
- Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation.Human genetics · 2007Article
- Testing for association based on excess allele sharing in a sample of related cases and controls.Human genetics · 2007Article
- GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.NeuropharmacologyReview
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Authors and funding
10 authors.
Funding
Abstract
We report on linkage analysis of a completely ascertained population of familial psychosis derived from the oceanic nation of Palau. Palau, an archipelago of islands in the Southern Pacific, currently has a population of approximately 23,000 individuals. The peoples of Palau populated these islands recently in human history, approximately 2,000 years ago. As both historical and genetic evidence suggest, the population is far more homogeneous than most other populations undergoing genetic studies, and should therefore prove quite useful for mapping genetic variants having a meaningful impact on susceptibility to psychotic disorders. Moreover, for our study, essentially all on-island schizophrenics (150) and individuals with other psychotic disorders (25) participated. By analysis of narrow (only schizophrenia) and broad (all psychosis) diagnostic schemes, two-point linkage analyses suggest that two regions of the genome harbor genetic variants affecting liability in most families, 3q28 (LOD = 3.03) and 17q32.2 (LOD = 2.80). Results from individual pedigrees also support 2q37.2, 2p14, and 17p13 as potentially harboring important genetic variants. Most of these regions have been implicated in other genetic studies of psychosis in populations physically quite distant from this Oceanic population, although some (e.g., 3q28) appear to be novel results for schizophrenia linkage analyses.
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