ArticleGut2005
Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Chronic hypoxia for the adaptation of extracellular vesicle phenotype.Scientific reports · 2024Article
- Hypobaric hypoxia induces iron mobilization from liver and spleen and increases serum iron via activation of ghrelin/GHSR1a/MAPK signalling pathway in mice.Scientific reports · 2023Article
- Chronic High-Altitude Hypoxia Alters Iron and Nitric Oxide Homeostasis in Fetal and Maternal Sheep Blood and Aorta.Antioxidants (Basel, Switzerland) · 2022Article
- Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis.Journal of translational internal medicine · 2022Article
- Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Hypoxia enhances HRedox biology · 2018Article
- Review
- Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Hypoxia-inducible factors link iron homeostasis and erythropoiesis.Gastroenterology · 2014Review
- The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.Przeglad gastroenterologiczny · 2014Review
- Review
- Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis.Haematologica · 2012Article
- Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia.The journal of nutrition, health & aging · 2011Article
- Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.American journal of physiology. Cell physiology · 2011Article
- Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.The Journal of biological chemistry · 2011Article
- Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia.Advances in hematology · 2011Article
- HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.The Journal of clinical investigation · 2009Article
- Liver-gut axis in the regulation of iron homeostasis.World journal of gastroenterology · 2007Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the requirement for increased iron delivery for erythropoiesis during hypoxia, there is very little information on how duodenal iron uptake and its transfer to the blood adapts to this condition.
aimsTo assess the effects of 30 days of chronic hypoxia in rats on luminal iron uptake and transfer of the metal to blood, together with gene expression of hepcidin, a proposed negative regulator of iron transport.
methods59-Fe uptake by isolated duodenum and its transfer to blood by in vivo duodenal segments was measured after exposure of rats to room air or 10% oxygen for four weeks. Liver hepcidin expression was measured by real time reverse transcription-polymerase chain reaction. The effects of hypoxia on hepcidin gene expression by HepG2 cells was also determined.
resultsHypoxia did not affect villus length but enhanced (+192.6%) luminal iron uptake by increasing the rate of uptake by all enterocytes, particularly those on the upper villus. Hypoxia promoted iron transfer to the blood but reduced mucosal iron accumulation in vivo by 66.7%. Hypoxia reduced expression of hepcidin mRNA in both rat liver and HepG2 cells.
conclusionsProlonged hypoxia enhances iron transport from duodenal lumen to blood but the process is unable to fully meet the iron requirement for increased erythropoiesis. Reduced secretion of hepcidin may be pivotal to the changes in iron absorption. The processes responsible for suppression of hepcidin expression are unknown but are likely to involve a direct effect of hypoxia on hepatocytes.
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