ArticleGut2005
Rectal sensorimotor dysfunction in patients with urge faecal incontinence: evidence from prolonged manometric studies.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Systematic review and meta-analysis of anal motor and rectal sensory dysfunction in male and female patients undergoing anorectal manometry for symptoms of faecal incontinence.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Pooled it
- Comparison of clinical and paraclinical characteristics of patients with urge, mixed, and passive fecal incontinence: a systematic literature review.International journal of colorectal disease · 2021Pooled it
- Chronic constipation: A review of literature.Medicine · 2018Pooled it
- Systematic review of the impact of sacral neuromodulation on clinical symptoms and gastrointestinal physiology.ANZ journal of surgery · 2016Pooled it
- Percutaneous tibial nerve stimulation (PTNS) in females with faecal incontinence: the impact of sphincter morphology and rectal sensation on the clinical outcome.International journal of colorectal disease · 2012Trial
- The Japan Society of Coloproctology Practice Guidelines for Fecal Incontinence 2024 (Revised Second Edition).Journal of the anus, rectum and colon · 2026Review
- Obesity Is Independently Associated With Increased Risk of Fecal Incontinence and Altered Rectal Sensitivity.The American journal of gastroenterology · 2025Article
- Urinary Dysfunction Is Common in Patients with Fecal Urgency and May Relate to Altered Rectal Biomechanics.Digestive diseases and sciences · 2025Article
- To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography.World journal of gastrointestinal surgery · 2024Article
- Rectal Sensory and Compliance Testing: A Method Comparison Study between High-Resolution Anorectal Manometry and Barostat Investigations.Diagnostics (Basel, Switzerland) · 2024Article
- The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces.Scientific reports · 2024Article
- Article
- Relationship between anal functional lumen imaging probe (EndoFLIP®) results and the clinical presentation of faecal incontinence.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Faecal incontinence in adults.Nature reviews. Disease primers · 2022Review
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis.Scientific reports · 2021Article
- Fatigability of the external anal sphincter muscles using a novel strength training resistance exercise device.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Scientific solution to a complex problem: physiology and multidisciplinary team improve understanding and outcome in chronic constipation and faecal incontinence.Pediatric surgery international · 2020Article
- Clinical measurement of gastrointestinal motility and function: who, when and which test?Nature reviews. Gastroenterology & hepatology · 2018Review
- Expert consensus document: Advances in the evaluation of anorectal function.Nature reviews. Gastroenterology & hepatology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAlthough external anal sphincter dysfunction is the major cause of urge faecal incontinence, approximately 50% of such patients have evidence of rectal hypersensitivity and report exaggerated stool frequency and urgency. The contribution of rectosigmoid contractile activity to the pathophysiology of this condition is unclear, and thus the relations between symptoms, rectal sensation, and rectosigmoid motor function were investigated.
methodsFifty two consecutive patients with urge faecal incontinence, referred to a tertiary surgical centre, and 24 volunteers, underwent comprehensive anorectal physiological investigation, including prolonged rectosigmoid manometry. Patients were classified on the basis of balloon distension thresholds into those with rectal hypersensitivity (n = 27) and those with normal rectal sensation (n = 25). Automated quantitative analysis of overall rectosigmoid contractile activities and, specifically, high amplitude contractions and rectal motor complex activity was performed.
resultsExternal anal sphincter dysfunction was similar in both patient groups. Overall, phasic activity and high amplitude contraction frequency were greater, and rectal motor complex variables significantly altered, in those with rectal hypersensitivity. Symptoms, more prevalent in the rectal hypersensitivity group, were also more often associated with rectosigmoid contractile events. For individuals, reduced compliance and increased rectal motor complex frequency were only observed in patients with rectal hypersensitivity.
conclusionsWe have identified a subset of patients with urge faecal incontinence-namely, those with rectal hypersensitivity-who demonstrated increased symptoms, enhanced perception, reduced compliance, and exaggerated rectosigmoid motor activity. Comprehensive assessment of rectosigmoid sensorimotor function, in addition to evaluation of anal function, should be considered in the investigation of patients with urge faecal incontinence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.