ArticleBlood2005
Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.
Article in Blood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Small intestinal microbial fiber metabolism dysfunction in celiac disease.Nature communications · 2026Article
- Collection Series "Iron Homeostasis".International journal of molecular sciences · 2025Article
- HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease.Biomedicines · 2025Review
- Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota.BMC microbiology · 2021Article
- Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains.BMC cancer · 2021Article
- Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis.Scientific reports · 2020Article
- Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet.PloS one · 2019Article
- Haemochromatosis.Nature reviews. Disease primers · 2018Review
- MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin.Frontiers in cell and developmental biology · 2018Article
- MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice.Frontiers in physiology · 2018Article
- The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system.Immunity, inflammation and disease · 2017Review
- Dietary Heme Induces Gut Dysbiosis, Aggravates Colitis, and Potentiates the Development of Adenomas in Mice.Frontiers in microbiology · 2017Article
- Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?Frontiers in immunology · 2017Review
- IncreasedFrontiers in cellular and infection microbiology · 2017Article
- Metabolic reprogramming and cell fate regulation in alcoholic liver disease.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2015Review
- Molecular basis of HFE-hemochromatosis.Frontiers in pharmacology · 2014Review
- Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.Journal of medical genetics · 2013Article
- Article
- Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells.Shock (Augusta, Ga.) · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading. In this study, we investigated the contribution of Hfe expression in macrophages to the regulation of liver hepcidin levels and iron loading. We used bone marrow transplantation to generate wild-type (wt) and Hfe-/- mice chimeric for macrophage Hfe gene expression. Reconstitution of Hfe-deficient mice with wt bone marrow resulted in augmented capacity of the spleen to store iron and in significantly decreased liver iron loading, accompanied by a significant increase of hepatic hepcidin mRNA levels. Conversely, wt mice reconstituted with Hfe-deficient bone marrow had a diminished capacity to store iron in the spleen but no significant alterations of liver iron stores or hepcidin mRNA levels. Our results suggest that macrophage Hfe participates in the regulation of splenic and liver iron concentrations and liver hepcidin expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.