ArticleThe Journal of cell biology2005
SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Pyramiding elite alleles of the genetically linked OsNRAMP5 and OsHMA3 confers low Cd accumulation in rice grains without compromising stress tolerance.Plant communications · 2026Article
- Functional characterization of transporter genes in rice node at single-cell resolution through multi-omics technologies.Genome biology · 2026Article
- Key challenges and recommendations for defining organelle membrane contact sites.Nature reviews. Molecular cell biology · 2025Review
- The tether function of the anoctamins.Cell calcium · 2024Review
- Structure and Function of Calcium-Activated Chloride Channels and Phospholipid Scramblases in the TMEM16 Family.Handbook of experimental pharmacology · 2024Review
- Endoplasmic Reticulum-Plasma Membrane Contact Sites: Regulators, Mechanisms, and Physiological Functions.Frontiers in cell and developmental biology · 2021Review
- Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.Developmental cell · 2019Article
- A Vacuolar Membrane Ferric-Chelate Reductase, OsFRO1, Alleviates Fe Toxicity in Rice (Frontiers in plant science · 2019Article
- A Plasma Membrane Association Module in Yeast Amino Acid Transporters.The Journal of biological chemistry · 2016Article
- The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.Cell calcium · 2015Review
- The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment.PloS one · 2012Article
- A crucial sequence for transglutaminase type 2 extracellular trafficking in renal tubular epithelial cells lies in its N-terminal beta-sandwich domain.The Journal of biological chemistry · 2011Article
- Role of endoplasmic reticulum domains in determining secretion routes.F1000 biology reports · 2010Article
- Prm1 targeting to contact sites enhances fusion during mating in Saccharomyces cerevisiae.Eukaryotic cell · 2010Article
- A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER.Journal of lipid research · 2010Article
- Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Prm1 functions as a disulfide-linked complex in yeast mating.The Journal of biological chemistry · 2010Article
- ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.Biochimica et biophysica acta · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classic studies of temperature-sensitive secretory (sec) mutants have demonstrated that secreted and plasma membrane proteins follow a common SEC pathway via the endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles to the cell periphery. The yeast protein Ist2p, which is synthesized from a localized mRNA, travels from the ER to the plasma membrane via a novel route that operates independently of the formation of coat protein complex II-coated vesicles. In this study, we show that the COOH-terminal domain of Ist2p is necessary and sufficient to mediate SEC18-independent sorting when it is positioned at the COOH terminus of different integral membrane proteins and exposed to the cytoplasm. This domain functions as a dominant plasma membrane localization determinant that overrides other protein sorting signals. Based on these observations, we suggest a local synthesis of Ist2p at cortical ER sites, from where the protein is sorted by a novel mechanism to the plasma membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.