ArticleNucleic acids research2005
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- A new class of human CpG Island promoters with primate-specific repeats.Scientific reports · 2025Article
- Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice.PloS one · 2018Article
- GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences.BMC genomics · 2017Article
- Epigenetic assimilation in the aging human brain.Genome biology · 2016Article
- Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.The international journal of neuropsychopharmacology · 2015Article
- DNA modification study of major depressive disorder: beyond locus-by-locus comparisons.Biological psychiatry · 2015Article
- CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data.Nucleic acids research · 2013Article
- Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia.PloS one · 2013Article
- Identification of CpG islands in DNA sequences using statistically optimal null filters.EURASIP journal on bioinformatics & systems biology · 2012Article
- CpG array analysis of histone H3 lysine 4 trimethylation by chromatin immunoprecipitation linked to microarrays analysis in peripheral blood mononuclear cells of IgA nephropathy patients.Yonsei medical journal · 2012Article
- The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells.Cell cycle (Georgetown, Tex.) · 2012Article
- Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells.Endocrine-related cancer · 2011Article
- Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders.Human molecular genetics · 2010Article
- Article
- The most redundant sequences in human CpG island library are derived from mitochondrial genome.Genomics, proteomics & bioinformatics · 2010Article
- Intergenic, gene terminal, and intragenic CpG islands in the human genome.BMC genomics · 2010Article
- CpG_MI: a novel approach for identifying functional CpG islands in mammalian genomes.Nucleic acids research · 2010Article
- Methods in DNA methylation profiling.Epigenomics · 2009Review
- Large-scale analysis of DNA methylation in chronic lymphocytic leukemia.Epigenomics · 2009Article
- A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
An effective tool for the global analysis of both DNA methylation status and protein-chromatin interactions is a microarray constructed with sequences containing regulatory elements. One type of array suited for this purpose takes advantage of the strong association between CpG Islands (CGIs) and gene regulatory regions. We have obtained 20,736 clones from a CGI Library and used these to construct CGI arrays. The utility of this library requires proper annotation and assessment of the clones, including CpG content, genomic origin and proximity to neighboring genes. Alignment of clone sequences to the human genome (UCSC hg17) identified 9595 distinct genomic loci; 64% were defined by a single clone while the remaining 36% were represented by multiple, redundant clones. Approximately 68% of the loci were located near a transcription start site. The distribution of these loci covered all 23 chromosomes, with 63% overlapping a bioinformatically identified CGI. The high representation of genomic CGI in this rich collection of clones supports the utilization of microarrays produced with this library for the study of global epigenetic mechanisms and protein-chromatin interactions. A browsable database is available on-line to facilitate exploration of the CGIs in this library and their association with annotated genes or promoter elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.