ArticleGenetics2005
High-diversity genes in the Arabidopsis genome.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism.Nature genetics · 2025Article
- Identification and characterization of RuvBL DNA helicase genes for tolerance against abiotic stresses in bread wheat (Triticum aestivum L.) and related species.Functional & integrative genomics · 2023Article
- Restriction associated DNA-genotyping at multiple spatial scales in Arabidopsis lyrata reveals signatures of pathogen-mediated selection.BMC genomics · 2018Article
- Sequence Exchange between Homologous NB-LRR Genes Converts Virus Resistance into Nematode Resistance, and Vice Versa.Plant physiology · 2017Article
- Long-term balancing selection at the Phosphorus Starvation Tolerance 1 (PSTOL1) locus in wild, domesticated and weedy rice (Oryza).BMC plant biology · 2016Article
- Nucleotide diversity patterns of three divergent soybean populations: evidences for population-dependent linkage disequilibrium and taxonomic status of Glycine gracilis.Ecology and evolution · 2015Article
- Sequence variation, differential expression, and divergent evolution in starch-related genes among accessions of Arabidopsis thaliana.Plant molecular biology · 2015Article
- DNA sequence variation of wild barley Hordeum spontaneum (L.) across environmental gradients in Israel.Heredity · 2014Article
- Continental-scale footprint of balancing and positive selection in a small rodent (Microtus arvalis).PloS one · 2014Article
- RNA-Seq effectively monitors gene expression in Eutrema salsugineum plants growing in an extreme natural habitat and in controlled growth cabinet conditions.BMC genomics · 2013Article
- Intraspecific sequence variation and differential expression in starch synthase genes of Arabidopsis thaliana.BMC research notes · 2013Article
- Bimodal expression level polymorphisms in Arabidopsis thaliana.Plant signaling & behavior · 2012Article
- Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.PLoS genetics · 2012Article
- Evolutionary and functional properties of a two-locus beta-globin polymorphism in Indian house mice.Genetics · 2010Article
- Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays.Genome biology · 2010Article
- Targets of balancing selection in the human genome.Molecular biology and evolution · 2009Article
- Scanning the genome for gene single nucleotide polymorphisms involved in adaptive population differentiation in white spruce.Molecular ecology · 2008Article
- High-throughput gene and SNP discovery in Eucalyptus grandis, an uncharacterized genome.BMC genomics · 2008Article
- Local patterns of nucleotide polymorphism are highly variable in the selfing species Arabidopsis thaliana.Journal of molecular evolution · 2008Article
- Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis.Journal of genetics · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-diversity genes represent an important class of loci in organismal genomes. Since elevated levels of nucleotide variation are a key component of the molecular signature for balancing selection or local adaptation, high-diversity genes may represent loci whose alleles are selectively maintained as balanced polymorphisms. Comparison of 4300 random shotgun sequence fragments of the Arabidopsis thaliana Ler ecotype genome with the whole genomic sequence of the Col-0 ecotype identified 60 genes with putatively high levels of intraspecific variability. Eleven of these genes were sequenced in multiple A. thaliana accessions, 3 of which were found to display elevated levels of nucleotide polymorphism. These genes encode the myb-like transcription factor MYB103, a putative soluble starch synthase I, and a homeodomain-leucine zipper transcription factor. Analysis of these genes and 4-7 flanking genes in 14-20 A. thaliana ecotypes revealed that two of these loci show other characteristics of balanced polymorphisms, including broad peaks of nucleotide diversity spanning multiple linked genes and an excess of intermediate-frequency polymorphisms. Scanning genomes for high-diversity genomic regions may be useful in approaches to adaptive trait locus mapping for uncovering candidate balanced polymorphisms.
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