ArticleGenetics2005
Germline bottlenecks, biparental inheritance and selection on mitochondrial variants: a two-level selection model.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Beginner's Guide for Using Bone in Marine Mammal Research.Integrative and comparative biology · 2026Guideline
- Coevolution of Codependent Hosts and Symbionts.bioRxiv : the preprint server for biology · 2026Article
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys.Frontiers in genetics · 2022Article
- iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome.Stem cell reports · 2021Article
- The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development.eLife · 2021Article
- Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck.PLoS biology · 2021Article
- Detection of high heteroplasmy in complete loggerhead and hawksbill sea turtles mitochondrial genomes using RNAseq.Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis · 2021Article
- MtDNA sequence features associated with 'selfish genomes' predict tissue-specific segregation and reversion.Nucleic acids research · 2020Article
- Population-specific signatures of intra-individual mitochondrial DNA heteroplasmy and their potential evolutionary advantages.Scientific reports · 2020Article
- Coadaptation of mitochondrial and nuclear genes, and the cost of mother's curse.Proceedings. Biological sciences · 2018Article
- Article
- Uniparental Inheritance Promotes Adaptive Evolution in Cytoplasmic Genomes.Molecular biology and evolution · 2017Article
- Selection for Mitochondrial Quality Drives Evolution of the Germline.PLoS biology · 2016Article
- Why are most organelle genomes transmitted maternally?BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes.Proceedings. Biological sciences · 2013Article
- Selection for mitonuclear co-adaptation could favour the evolution of two sexes.Proceedings. Biological sciences · 2012Article
- The intriguing evolutionary dynamics of plant mitochondrial DNA.BMC biology · 2011Article
- Novel protein genes in animal mtDNA: a new sex determination system in freshwater mussels (Bivalvia: Unionoida)?Molecular biology and evolution · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selection on mitochondrial mutations potentially occurs at different levels: at the mitochondria, cell, and organism levels. Several factors affect the strength of selection at these different levels; in particular, mitochondrial bottlenecks during germline development and reduced paternal transmission decrease the genetic variance within cells, while they increase the variance between cells and between organisms, thus decreasing the strength of selection within cells and increasing the strength of selection between cells and organisms. However, bottlenecks and paternal transmission also affect the effective mitochondrial population size, thus affecting genetic drift. In this article, we use a simple model of a unicellular life cycle to investigate the effects of bottlenecks and paternal transmission on the probability of fixation of mitochondrial mutants and their frequency at mutation-selection equilibrium. We find that bottlenecks and reduced paternal transmission decrease the mean frequency of alleles with sm>sc (approximately), where sm and sc are the strengths of selection for an allele within and between cells, respectively, and increase the frequency of alleles with sm<sc. Effects on fixation probabilities are different; for example, bottlenecks reduce the fixation probability of mutants with sm>0 (unless sm is very small relative to sc) and increase the fixation probability of mutants with sm<0.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.