ArticleBiochemistry2005
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.
Article in Biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites.Biology · 2017Article
- Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.Journal of fluorine chemistry · 2016Article
- Expression of Functional Recombinant Human Tissue Transglutaminase (TG2) Using the Bac-to-Bac Baculovirus Expression System.Advanced pharmaceutical bulletin · 2016Article
- Qualitative Characterization of the Rat Liver Mitochondrial Lipidome using LC-MS Profiling and High Energy Collisional Dissociation (HCD) All Ion Fragmentation.Metabolomics : Official journal of the Metabolomic Society · 2013Article
- Transglutaminase 2: a molecular Swiss army knife.Biochimica et biophysica acta · 2012Review
- Possible role of the transglutaminases in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.International journal of Alzheimer's disease · 2011Article
- Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.Free radical biology & medicine · 2010Article
- Physio-pathological roles of transglutaminase-catalyzed reactions.World journal of biological chemistry · 2010Article
- Measurement of cysteine S-conjugate β-lyase activity.Current protocols in toxicology · 2010Article
- Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Biochimica et biophysica acta · 2010Review
- A nonradioactive dot blot assay for transglutaminase activity.Analytical biochemistry · 2009Article
- Intracellular localization and conformational state of transglutaminase 2: implications for cell death.PloS one · 2009Article
- Transglutaminases and neurodegeneration.Journal of neurochemistry · 2009Review
- Metabolism of the cysteine S-conjugate of busulfan involves a beta-lyase reaction.Drug metabolism and disposition: the biological fate of chemicals · 2008Article
- Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.Archives of biochemistry and biophysics · 2007Article
- Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.Neurochemical research · 2005Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Several active transglutaminase (TGase) isoforms are known to be present in human and rodent tissues, at least three of which, namely, TGase 1, TGase 2 (tissue transglutaminase), and TGase 3, are present in the brain. TGase activity is known to be present in the cytosolic, nuclear, and extracellular compartments of the brain. Here, we show that highly purified mouse brain nonsynaptosomal mitochondria and mouse liver mitochondria and mitoplast fractions derived from these preparations possess TGase activity. Western blotting and experiments with TGase 2 knock-out (KO) mice ruled out the possibility that most of the mitochondrial/mitoplast TGase activity is due to TGase 2, the TGase isoform responsible for the majority of the activity ([14C]putrescine-binding assay) in whole brain and liver homogenates. The identity of the mitochondrial/mitoplast TGase(s) is not yet known. Possibly, the activity may be due to one of the other TGase isoforms or perhaps to a protein that does not belong to the classical TGase family. This activity may play a role in regulation of mitochondrial function both in normal physiology and in disease. Its nature and regulation deserve further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.