ArticleJournal of molecular evolution2005
Type I polyketide synthases may have evolved through horizontal gene transfer.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
- Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
- Diversity and Distribution of Non-Reducing Polyketide Synthases (NR-PKSs) in Ascomycota (Fungi).Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Pangenome mining of the Streptomyces genus redefines species' biosynthetic potential.Genome biology · 2025Article
- Genome Mining ofMolecules (Basel, Switzerland) · 2021Article
- Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities.Scientific reports · 2021Article
- Insights into the Variation in Bioactivities of Closely RelatedMarine drugs · 2021Article
- Mining of Cyanobacterial Genomes Indicates Natural Product Biosynthetic Gene Clusters Located in Conjugative Plasmids.Frontiers in microbiology · 2021Article
- Evolution and Diversity of Assembly-Line Polyketide Synthases.Chemical reviews · 2019Review
- Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases.Nature communications · 2019Article
- Emerging evolutionary paradigms in antibiotic discovery.Journal of industrial microbiology & biotechnology · 2019Review
- Identification of Secondary Metabolite Gene Clusters in theFrontiers in microbiology · 2017Article
- Natural Products and the Gene Cluster Revolution.Trends in microbiology · 2016Review
- Horizontal Gene Transfer of the Non-ribosomal Peptide Synthetase Gene Among Endophytic and Epiphytic Bacteria Associated with Ethnomedicinal Plants.Current microbiology · 2016Article
- Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.BMC genomics · 2014Article
- Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Marine Actinobacteria from the Gulf of California: diversity, abundance and secondary metabolite biosynthetic potential.Antonie van Leeuwenhoek · 2013Article
- Gene sequence based clustering assists in dereplication of Pseudoalteromonas luteoviolacea strains with identical inhibitory activity and antibiotic production.Marine drugs · 2012Article
- Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'.Environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.