ArticleJournal of molecular evolution2005
Protein evolution in the context of Drosophila development.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Transcriptome Profiling Reveals Genes Related to Sex Determination and Differentiation in Sugarcane Borer (Insects · 2022Article
- Speciation and the developmental alarm clock.eLife · 2020Review
- Sexual dimorphism and sex-biased gene expression in an egg parasitoid species, Anastatus disparis.BMC genomics · 2020Article
- Molecular evolution across developmental time reveals rapid divergence in early embryogenesis.Evolution letters · 2019Article
- Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.Genome biology and evolution · 2019Article
- Adaptation and Conservation throughout the Drosophila melanogaster Life-Cycle.Genome biology and evolution · 2019Article
- Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Developmental Constraints on Genome Evolution in Four Bilaterian Model Species.Genome biology and evolution · 2018Article
- Convergent occurrence of the developmental hourglass in plant and animal embryogenesis?Annals of botany · 2016Review
- Evidence for active maintenance of phylotranscriptomic hourglass patterns in animal and plant embryogenesis.Molecular biology and evolution · 2015Article
- Conserved temporal patterns of microRNA expression in Drosophila support a developmental hourglass model.Genome biology and evolution · 2014Article
- Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans.Molecular biology and evolution · 2014Article
- Fast-evolving microRNAs are highly expressed in the early embryo of Drosophila virilis.RNA (New York, N.Y.) · 2014Article
- Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates.PloS one · 2014Article
- Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development.Genome biology and evolution · 2013Article
- Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome.Genome biology and evolution · 2012Article
- Sex and speciation: Drosophila reproductive tract proteins- twenty five years later.International journal of evolutionary biology · 2012Article
- Article
- A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns.Nature · 2010Article
- Functional and evolutionary correlates of gene constellations in the Drosophila melanogaster genome that deviate from the stereotypical gene architecture.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tempo at which a protein evolves depends not only on the rate at which mutations arise but also on the selective effects that those mutations have at the organismal level. It is intuitive that proteins functioning during different stages of development may be predisposed to having mutations of different selective effects. For example, it has been hypothesized that changes to proteins expressed during early development should have larger phenotypic consequences because later stages depend on them. Conversely, changes to proteins expressed much later in development should have smaller consequences at the organismal level. Here we assess whether proteins expressed at different times during Drosophila development vary systematically in their rates of evolution. We find that proteins expressed early in development and particularly during mid-late embryonic development evolve unusually slowly. In addition, proteins expressed in adult males show an elevated evolutionary rate. These two trends are independent of each other and cannot be explained by peculiar rates of mutation or levels of codon bias. Moreover, the observed patterns appear to hold across several functional classes of genes, although the exact developmental time of the slowest protein evolution differs among each class. We discuss our results in connection with data on the evolution of development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.