Evidence map›Paper›PMID 15909175›Full record

ReviewDer Orthopade2005

[The enthesis. Physiological morphology, molecular composition and pathoanatomical alterations].

S Milz, B M Boszczyk, A A Boszczyk, R Putz, M Benjamin

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Orthopade, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

S MilzAO Forschungsinstitut, Davos, Schweiz. stefan.milz@aofoundation.org
B M Boszczyk
A A Boszczyk
R Putz
M Benjamin
AO Foundation · CHCardiff University · GBUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the extracellular matrix in tendons and ligaments is directly related to the mechanical environment. Local compression triggers functional adaptation that leads to cartilage-specific transformation of the tissue. The molecular composition of the extracellular matrix at the enthesis is related to the amount of stress and to the geometry of the insertion. Comparison of physiologically and non-physiologically loaded entheses shows that only certain molecules occur under relatively high amounts of local compressive stress. The occurrence of certain cartilage specific molecules is clinically relevant, because some of these molecules have been identified as autoantigens during the autoimmune response in patients with rheumatoid arthritis. These molecules constitute potential targets for the manifestation of rheumatoid arthritis at fibrocartilaginous entheses.

Indexed as

AnimalsArthritis, RheumatoidCompressive StrengthExtracellular MatrixExtracellular Matrix ProteinsHumansLigamentsMechanotransduction, CellularTendonsExtracellular Matrix Proteins

Identifiers

PMID15909175
OpenAlexW2033450363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.