ArticleDiabetologia2005
Expression of 14-3-3 zeta and interaction with protein kinase C in the rat retina in early diabetes.
Article in Diabetologia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Analysis of 14-3-3 isoforms expressed in photoreceptors.Experimental eye research · 2018Article
- Suppressor of fused (Sufu) promotes epithelial-mesenchymal transition (EMT) in cervical squamous cell carcinoma.Oncotarget · 2017Article
- Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy.International journal of ophthalmology · 2014Article
- Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.PloS one · 2014Article
- 14-3-3 Proteins are Regulators of Autophagy.Cells · 2012Article
- Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.American journal of physiology. Endocrinology and metabolism · 2011Article
- CaMKII regulates pericyte loss in the retina of early diabetic mouse.Molecules and cells · 2011Article
- Gene expression changes in a rat model of oxygen-induced retinopathy.Korean journal of ophthalmology : KJO · 2011Article
- Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina.Diabetes · 2010Article
- Article
- Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.Diabetes · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe present study aimed to investigate the expression levels of and the relationship between 14-3-3 zeta and protein kinase C (PKC) in the retina of early diabetes.
methodsChanges in the expression levels of, and interaction between, 14-3-3 zeta and PKC were investigated by Northern and Western blot analyses, immunoprecipitation and double immunostaining in the retina of diabetic rats after 6 weeks of diabetes. PKC activity was examined using a PKC assay.
resultsIn the diabetic retina, the molecular levels of 14-3-3 zeta were reduced, while those of PKC beta and zeta were increased. Direct interaction between 14-3-3 zeta and PKC was markedly decreased in the retina after 6 weeks of diabetes, while PKC activity was increased. CONCLUSIONS/
interpretationThese findings show that a reduction in 14-3-3 zeta can induce PKC activation, suggesting that this is a main cause of visual dysfunction in the retina during diabetes.
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