ArticleApoptosis : an international journal on programmed cell death2005
Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.
Article in Apoptosis : an international journal on programmed cell death, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis.Frontiers in pharmacology · 2023Review
- Cell Killing by Reovirus: Mechanisms and Consequences.Current topics in microbiology and immunology · 2023Review
- Article
- Loss of IKK Subunits Limits NF-κB Signaling in Reovirus-Infected Cells.Journal of virology · 2020Article
- NF-κB activation is cell type-specific in the heart.Virology · 2017Article
- Novel antiviral activity of mung bean sprouts against respiratory syncytial virus and herpes simplex virus -1: an in vitro study on virally infected Vero and MRC-5 cell lines.BMC complementary and alternative medicine · 2015Article
- An ITAM in a nonenveloped virus regulates activation of NF-κB, induction of beta interferon, and viral spread.Journal of virology · 2014Article
- Article
- Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis.Journal of virology · 2013Article
- Reovirus receptors, cell entry, and proapoptotic signaling.Advances in experimental medicine and biology · 2013Review
- Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-κB-dependent expression of Noxa.Journal of virology · 2012Article
- Modulation of NF-κB signalling by microbial pathogens.Nature reviews. Microbiology · 2011Review
- A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism.The Journal of biological chemistry · 2010Article
- Role of cellular caspases, nuclear factor-kappa B and interferon regulatory factors in Bluetongue virus infection and cell fate.Virology journal · 2010Article
- Critical role for death-receptor mediated apoptotic signaling in viral myocarditis.Journal of cardiac failure · 2010Article
- Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance.Journal of virology · 2010Article
- Gene expression in the brain during reovirus encephalitis.Journal of neurovirology · 2010Article
- Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.Journal of virology · 2009Article
- Death receptor-associated pro-apoptotic signaling in aged skeletal muscle.Apoptosis : an international journal on programmed cell death · 2006Article
- Genes Induced by Reovirus Infection Have a Distinct Modular Cis-Regulatory Architecture.Current genomics · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Virus-induced activation of nuclear factor-kappa B (NF-kappaB) is required for Type 3 (T3) reovirus-induced apoptosis. We now show that NF-kappaB is also activated by the prototypic Type 1 reovirus strain Lang (T1L), which induces significantly less apoptosis than T3 viruses, indicating that NF-kappaB activation alone is not sufficient for apoptosis in reovirus-infected cells. A second phase of virus-induced NF-kappaB regulation, where NF-kappaB activation is inhibited at later times following infection with T3 Abney (T3A), is absent in T1L-infected cells. This suggests that inhibition of NF-kappaB activation at later times post infection also contributes to reovirus-induced apoptosis. Reovirus-induced inhibition of stimulus-induced activation of NF-kappaB is significantly associated with apoptosis following infection of HEK293 cells with reassortant reoviruses and is determined by the T3 S1 gene segment, which is also the primary determinant of reovirus-induced apoptosis. Inhibition of stimulus-induced activation of NF-kappaB also occurs following infection of primary cardiac myocytes with apoptotic (8B) but not non-apoptotic (T1L) reoviruses. Expression levels of the NF-kappaB-regulated cellular FLICE inhibitory protein (cFLIP) reflect NF-kappaB activation in reovirus-infected cells. Further, inhibition of NF-kappaB activity and cFLIP expression promote T1L-induced apoptosis. These results demonstrate that inhibition of stimulus-induced activation of NF-kappaB and the resulting decrease in cFLIP expression promote reovirus-induced apoptosis.
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