ArticleBone marrow transplantation2005
Chagas disease in bone marrow transplantation: an approach to preemptive therapy.
Article in Bone marrow transplantation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.Arquivos brasileiros de cardiologia · 2023Guideline
- Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2009Guideline
- Chagas disease in immunocompromised patients.Clinical microbiology reviews · 2024Review
- Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Chagas Disease in Europe.Tropical medicine and infectious disease · 2023Review
- Article
- Aplastic Anemia and Chagas Disease:Tropical medicine and infectious disease · 2022Article
- Chagas disease reactivation after autologous stem cell transplant. Case report and literature reviewBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Emerging and reemerging forms of Trypanosoma cruzi transmission.Memorias do Instituto Oswaldo Cruz · 2022Review
- Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Prevalence of Chagas Disease among Solid Organ-Transplanted Patients in a Nonendemic Country.The American journal of tropical medicine and hygiene · 2018Article
- Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients.Clinics (Sao Paulo, Brazil) · 2017Article
- Imported Disease Screening Prior to Chemotherapy and Bone Marrow Transplantation for Oncohematological Malignancies.The American journal of tropical medicine and hygiene · 2016Article
- First Documented Transmission of Trypanosoma cruzi Infection through Blood Transfusion in a Child with Sickle-Cell Disease in Belgium.PLoS neglected tropical diseases · 2015Article
- Transplantation in the tropics: lessons on prevention and management of tropical infectious diseases.Current infectious disease reports · 2015Article
- Integrated control of Chagas disease for its elimination as public health problem--a review.Memorias do Instituto Oswaldo Cruz · 2015Article
- Inflammatory responses and intestinal injury development during acute Trypanosoma cruzi infection are associated with the parasite load.Parasites & vectors · 2015Article
- Reactivation of Chagas Disease in a Patient With Follicular Lymphoma Diagnosed by Means of Quantitative Real-Time Polymerase Chain Reaction.Open forum infectious diseases · 2015Article
- Reactivation of Chagas disease after a bone marrow transplant.Blood transfusion = Trasfusione del sangue · 2014Article
- Reactivation of Chagas disease in a bone marrow transplant patient: case report and review of screening and management.Transplant infectious disease : an official journal of the Transplantation Society · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of preemptive therapy was evaluated in bone marrow transplantation (BMT) recipients associated with Chagas disease (CD). The criterion to include patients in the protocol was the serological reactivity for CD in recipients and/or donors before transplant. After BMT, the monitoring was performed using the direct Strout method (SM), which detects clinical levels of Trypanosome cruzi parasitemia, and CD conventional serological tests. Monitoring took place during 60 days in ABMT and throughout the immunosuppressive period in allogeneic BMT. Reactivation of CD was diagnosed by detecting T. cruzi parasites in blood or tissues. In primary T. cruzi infection, an additional diagnostic criterion was the serological conversion. A total of 25 CD-BMT patients were included. Two ABMT and four allogeneic BMT recipients showed CD recurrences diagnosed by SM. One patient also showed skin lesions with T. cruzi amastigotes. Benznidazole treatment (Roche Lab), an antiparasitic drug, was prescribed at a dose of 5 mg/kg/day during 4-8 weeks with recovery of patients. Primary T. cruzi infection was not observed. This report proves the relevance of monitoring CD in BMT patients and demonstrates that preemptive therapy was able to abrogate the development of clinical and systemic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.