ArticlePlant physiology2005
Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Genome-wide identification, characterization and expression analysis of the subtilisin-like protease gene family in Quercus ilex in response to Phytophthora cinnamomi.Scientific reports · 2026Article
- Genome-Wide Identification and Analysis of the Maize Serine Peptidase S8 Family Genes in Response to Drought at Seedling Stage.Plants (Basel, Switzerland) · 2023Article
- Proteome profiles during early stage of somatic embryogenesis of two Eucalyptus species.BMC plant biology · 2022Article
- Insights into the Molecular Basis of Genome Stability and Pristine Proteostasis in Naked Mole-Rats.Advances in experimental medicine and biology · 2021Article
- Do plants use root-derived proteases to promote the uptake of soil organic nitrogen?Plant and soil · 2020Article
- Proteomics Analysis Reveals That Caspase-Like and Metacaspase-Like Activities Are Dispensable for Activation of Proteases Involved in Early Response to Biotic Stress inInternational journal of molecular sciences · 2018Article
- The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire.Plant biotechnology journal · 2018Article
- The Plastid and Mitochondrial Peptidase Network inThe Plant cell · 2017Review
- The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.Journal of experimental botany · 2016Article
- Specific pools of endogenous peptides are present in gametophore, protonema, and protoplast cells of the moss Physcomitrella patens.BMC plant biology · 2015Article
- Proteasome targeting of proteins in Arabidopsis leaf mesophyll, epidermal and vascular tissues.Frontiers in plant science · 2015Article
- Identification of multiple salicylic acid-binding proteins using two high throughput screens.Frontiers in plant science · 2014Article
- Article
- Mining the Active Proteome of Arabidopsis thaliana.Frontiers in plant science · 2011Article
- Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes.The Journal of biological chemistry · 2010Article
- The Enigma of Tripeptidyl-Peptidase II: Dual Roles in Housekeeping and Stress.Journal of oncology · 2010Article
- Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway: ACTIVATION IN RESPONSE TO CADMIUM.The Journal of biological chemistry · 2009Article
- Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The protease-associated domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SlSBT3).The Journal of biological chemistry · 2009Article
- Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana.Molecular & cellular proteomics : MCP · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The breakdown of most nuclear and cytoplasmic proteins involves their partial cleavage by the 26S proteasome followed by further disassembly to free amino acids by the combined action of endo- and exopeptidases. In animals, one important intermediate exopeptidase is tripeptidyl peptidase (TPP)II, which digests peptide products of the 26S proteasome and other endopeptidases into tripeptides. Here, we describe the purification and characterization of TPPII from Arabidopsis (Arabidopsis thaliana). Like its animal counterparts, Arabidopsis TPPII exists as a soluble, approximately 5- to 9-MD complex. Two related species of 153 and 142 kD are present in the purified preparations that are derived from a single TPP2 gene. Sequencing by Edman degradation of the intact polypeptides and mass spectrometry of proteolytic fragments demonstrated that the 142-kD form mainly differs from the 153-kD form by a truncation at the C-terminal end. This serine protease is a member of the subtilisin superfamily and is sensitive to the inhibitors alanine-alanine-phenylalanine-chloromethylketone and butabindide, which are diagnostic for the TPPII subfamily. The Arabidopsis TPP2 gene is widely expressed in many tissue types with related genes evident in other plant genomes. Whereas the 26S proteasome is essential, TPPII appears not as important for plant physiology. An Arabidopsis T-DNA mutant defective in TPP2 expression displays no phenotypic abnormalities and is not hypersensitive to either amino acid analogs or the 26S proteasome inhibitor MG132. As a consequence, plants likely contain other intermediate exopeptidases that assist in amino acid recycling.
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Registered trials
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