ArticlePlant physiology2005
Brassinosteroid homeostasis in Arabidopsis is ensured by feedback expressions of multiple genes involved in its metabolism.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 240 citations in OpenAlex.
- Brassinosteroids as Central Regulators of Plant Growth, Stress Tolerance, and Agricultural Resilience.Plants (Basel, Switzerland) · 2026Review
- A mechanistic framework for the recognition of chemically diverse brassinosteroids by BRI1-family receptor kinases.Nature plants · 2026Article
- Cell-type specific early perception of nine phytohormones revealed by single-nucleus transcriptomics in Arabidopsis.Nature communications · 2026Article
- Nitric oxide interacts with brassinosteroid signalling to regulate plant growth and development in an organ-specific manner.Journal of experimental botany · 2026Article
- First brassinosteroid-based dwarf mutant discovered and characterized in grapevine.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- Brassinosteroids in Cucurbits: Modulators of Plant Growth Architecture and Stress Response.International journal of molecular sciences · 2025Review
- Induced variation in BRASSINOSTEROID INSENSITIVE 1 (BRI1) confers a compact wheat architecture.BMC plant biology · 2025Article
- A system genetics analysis uncovers the regulatory variants controlling drought response in wheat.Plant biotechnology journal · 2025Article
- Genome-wide analysis and functional validation of the cotton FAH gene family for salt stress.BMC genomics · 2025Article
- Crucial Roles of Brassinosteroids in Cell Wall Composition and Structure Across Species: New Insights and Biotechnological Applications.Plant, cell & environment · 2025Review
- Gene mapping and candidate gene analysis of a sorghum sheathed panicle-I mutant.The plant genome · 2025Article
- The miR3367-lncRNA67-GhCYP724B module regulates male sterility by modulating brassinosteroid biosynthesis and interacting with Aorf27 in Gossypium hirsutum.Journal of integrative plant biology · 2025Article
- The calcium sensor AtCML8 contributes to Arabidopsis plant cell growth by modulating the brassinosteroid signaling pathway.The Plant journal : for cell and molecular biology · 2025Article
- Maritime Pine Rootstock Genotype Modulates Gene Expression Associated with Stress Tolerance in Grafted Stems.Plants (Basel, Switzerland) · 2024Article
- BoaBZR1.1 mediates brassinosteroid-induced carotenoid biosynthesis in Chinese kale.Horticulture research · 2024Article
- CRISPR/Cas9-mediated editing of GmDWF1 brassinosteroid biosynthetic gene induces dwarfism in soybean.Plant cell reports · 2024Article
- The Maize ZmBES1/BZR1-9 Transcription Factor Accelerates Flowering in TransgenicPlants (Basel, Switzerland) · 2023Article
- Comparative transcriptome profiling reveals the multiple levels of crosstalk in phytohormone networks in Brassica napus.Plant biotechnology journal · 2023Article
- Transcriptomic analysis of Chinese yam (Frontiers in nutrition · 2023Article
52 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeostasis of brassinosteroids (BRs) is essential for normal growth and development in higher plants. We examined responsiveness of 11 BR metabolic gene expressions to the decrease or increase of endogenous BR contents in Arabidopsis (Arabidopsis thaliana) to expand our knowledge of molecular mechanisms underlying BR homeostasis. Five BR-specific biosynthesis genes (DET2, DWF4, CPD, BR6ox1, and ROT3) and two sterol biosynthesis genes (FK and DWF5) were up-regulated in BR-depleted wild-type plants grown under brassinazole, a BR biosynthesis inhibitor. On the other hand, in BR-excessive wild-type plants that were fed with brassinolide, four BR-specific synthesis genes (DWF4, CPD, BR6ox1, and ROT3) and a sterol synthesis gene (DWF7) were down-regulated and a BR inactivation gene (BAS1) was up-regulated. However, their response to fluctuation of BR levels was highly reduced (DWF4) or nullified (the other eight genes) in a bri1 mutant. Taken together, our results imply that BR homeostasis is maintained through feedback expressions of multiple genes, each of which is involved not only in BR-specific biosynthesis and inactivation, but also in sterol biosynthesis. Our results also indicate that their feedback expressions are under the control of a BRI1-mediated signaling pathway. Moreover, a weak response in the mutant suggests that DWF4 alone is likely to be regulated in other way(s) in addition to BRI1 mediation.
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