ArticlePlant physiology2005
Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed, 154 citations in OpenAlex.
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- Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1.Plant communications · 2025Article
- Quantitative analysis of the root posture ofQuantitative plant biology · 2024Article
- Comparative Transcriptome Analysis Points to the Biological Processes of Hybrid Incompatibility betweenPlants (Basel, Switzerland) · 2023Article
- Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium.Nature plants · 2023Article
- Data-Independent Acquisition Proteomics Reveals the Effects of Red and Blue Light on the Growth and Development of Moso Bamboo (International journal of molecular sciences · 2023Article
- Genomic divergence between two sisterEcology and evolution · 2022Article
- Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux.The Plant cell · 2022Article
- Loss of Multiple ABCB Auxin Transporters Recapitulates the MajorFrontiers in plant science · 2022Article
- 2021 update on ATP-binding cassette (ABC) transporters: how they meet the needs of plants.Plant physiology · 2021Review
- Comprehensive Analysis and Expression Profiling of PIN, AUX/LAX, and ABCB Auxin Transporter Gene Families inBiology · 2021Article
- MicroRNA Profiling During Mulberry (Frontiers in plant science · 2021Article
- An ATP-Binding Cassette Transporter, ABCB19, Regulates Leaf Position and Morphology during Phototropin1-Mediated Blue Light Responses.Plant physiology · 2020Article
- Photoreceptors Regulate Plant Developmental Plasticity through Auxin.Plants (Basel, Switzerland) · 2020Review
- Auxin regulates endosperm cellularization inGenes & development · 2019Article
- Connective auxin transport contributes to strigolactone-mediated shoot branching control independent of the transcription factor BRC1.PLoS genetics · 2019Article
- The Arabidopsis ATP-BINDING CASSETTE Transporter ABCB21 Regulates Auxin Levels in Cotyledons, the Root Pericycle, and Leaves.Frontiers in plant science · 2019Article
- Auxin: a molecular trigger of seed development.Genes & development · 2018Review
9 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Light and auxin control many aspects of plant growth and development in an overlapping manner. We report here functional characterization of two closely related ABC (ATP-binding cassette) transporter genes, AtMDR1 and AtPGP1, in light and auxin responses. We showed that loss-of-function atmdr1 and atpgp1 mutants display hypersensitivity to far-red, red, and blue-light inhibition of hypocotyl elongation, reduced chlorophyll and anthocyanin accumulation, and abnormal expression of several light-responsive genes, including CAB3, RBCS, CHS, and PORA, under both darkness and far-red light conditions. In addition, we showed that the atmdr1-100 and atmdr1-100/atpgp1-100 mutants are defective in multiple aspects of root development, including increased root-growth sensitivity to 1-naphthalene acetic acid (1-NAA), and decreased sensitivity to naphthylphthalamic acid (NPA)-mediated inhibition of root elongation. Consistent with the proposed role of AtMDR1 in basipetal auxin transport, we found that expression of the auxin responsive DR5::GUS reporter gene in the central elongation zone is significantly reduced in the atmdr1-100 mutant roots treated with 1-NAA at the root tips, compared to similarly treated wild-type plants. Moreover, atmdr1-100, atpgp1-100, and their double mutants produced fewer lateral roots, in the presence or absence of 1-NAA or NPA. The atmdr1-100 and atmdr1-100/atpgp1-100 mutants also displayed enhanced root gravitropism. Genetic-epistasis analysis revealed that mutations in phyA largely suppress the randomized-hypocotyl growth and the short-hypocotyl phenotype of the atmdr1-100 mutants under far-red light, suggesting that phyA acts downstream of AtMDR1. Together, our results suggest that AtMDR1 and AtPGP1 regulate Arabidopsis (Arabidopsis thaliana) photomorphogenesis and multiple aspects of root development by mediating polar auxin transport.
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