ArticleNucleic acids research2005
Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
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- Quantum tunneling time delay investigation ofJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023Article
- Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences.Nucleic acids research · 2022Article
- Mechanisms of Binding Specificity among bHLH Transcription Factors.International journal of molecular sciences · 2021Review
- Ultrafast excited state dynamics and light-switching of [Ru(phen)Communications chemistry · 2021Article
- Structure and Function of Multimeric G-Quadruplexes.Molecules (Basel, Switzerland) · 2019Review
- Bulged and Canonical G-Quadruplex Conformations Determine NDPK Binding Specificity.Molecules (Basel, Switzerland) · 2019Article
- G-Quadruplex DNA and RNA.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Rapid detection of exosomal microRNA biomarkers by electrokinetic concentration for liquid biopsy on chip.Biomicrofluidics · 2018Article
- Myoblast Myogenic Differentiation but Not Fusion Process Is Inhibited via MyoD Tetraplex Interaction.Oxidative medicine and cellular longevity · 2018Article
- MyoD Is a Novel Activator of Porcine FIT1 Gene by Interacting with the Canonical E-Box Element during Myogenesis.International journal of molecular sciences · 2015Article
- Sequence, stability, and structure of G-quadruplexes and their interactions with drugs.Current protocols in nucleic acid chemistry · 2012Review
- Structural insights into G-quadruplexes: towards new anticancer drugs.Future medicinal chemistry · 2010Review
- Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression.Nucleic acids research · 2010Article
- Genome-wide colonization of gene regulatory elements by G4 DNA motifs.Nucleic acids research · 2009Article
- The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts.Nucleic acids research · 2009Article
- Natural isoflavones regulate the quadruplex-duplex competition in human telomeric DNA.Nucleic acids research · 2009Article
- Methods to determine DNA structural alterations and genetic instability.Methods (San Diego, Calif.) · 2009Review
- Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression.Nucleic acids research · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clustered guanine residues in DNA readily generate hairpin or a variety of tetrahelical structures. The myogenic determination protein MyoD was reported to bind to a tetrahelical structure of guanine-rich enhancer sequence of muscle creatine kinase (MCK) more tightly than to its target E-box motif [K. Walsh and A. Gualberto (1992) J. Biol. Chem., 267, 13714-13718], suggesting that tetraplex structures of regulatory sequences of muscle-specific genes could contribute to transcriptional regulation. In the current study we show that promoter or enhancer sequences of various muscle-specific genes display a disproportionately high incidence of guanine clusters. The sequences derived from the guanine-rich promoter or enhancer regions of three muscle-specific genes, human sarcomeric mitochondrial creatine kinase (sMtCK), mouse MCK and alpha7 integrin formed diverse secondary structures. The sMtCK sequence folded into a hairpin structure; the alpha7 integrin oligonucleotide generated a unimolecular tetraplex; and sequences from all three genes associated to generate bimolecular tetraplexes. Furthermore, two neighboring non-contiguous guanine-rich tracts in the alpha7 integrin promoter region also paired to form a tetraplex structure. We also show that homodimeric MyoD bound bimolecular tetraplex structures of muscle-specific regulatory sequences more efficiently than its target E-box motif. These results are consistent with a role of tetrahelical structures of DNA in the regulation of muscle-specific gene expression.
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