ArticleNucleic acids research2005
The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 91 citations in OpenAlex.
- Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026Review
- Conservation of dichromatin organization along regional centromeres.Cell genomics · 2025Article
- Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A.Nucleic acids research · 2024Article
- The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.Nucleic acids research · 2022Article
- Recent insights into mechanisms preventing ectopic centromere formation.Open biology · 2021Review
- Hap2-Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin.Genes & development · 2020Article
- Plant centromeres: genetics, epigenetics and evolution.Molecular biology reports · 2018Review
- Article
- Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AEpigenetics & chromatin · 2018Article
- The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3.Nature communications · 2017Article
- Chromatin assembly: Journey to the CENter of the chromosome.The Journal of cell biology · 2016Review
- No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.Cellular and molecular life sciences : CMLS · 2016Review
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A.Genes & development · 2014Article
- Genomic evidence for adaptation by gene duplication.Genome research · 2014Article
- Regulating the chromatin landscape: structural and mechanistic perspectives.Annual review of biochemistry · 2014Review
- Transcription and ncRNAs: at the cent(rome)re of kinetochore assembly and maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Putting CENP-A in its place.Cellular and molecular life sciences : CMLS · 2013Review
- DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.PLoS genetics · 2013Article
- CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe.The EMBO journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centromeres of fission yeast are arranged with a central core DNA sequence flanked by repeated sequences. The centromere-associated histone H3 variant Cnp1 (SpCENP-A) binds exclusively to central core DNA, while the heterochromatin proteins and cohesins bind the surrounding outer repeats. CHD (chromo-helicase/ATPase DNA binding) chromatin remodeling factors were recently shown to affect chromatin assembly in vitro. Here, we report that the CHD protein Hrp1 plays a key role at fission yeast centromeres. The hrp1Delta mutant disrupts silencing of the outer repeats and central core regions of the centromere and displays chromosome segregation defects characteristic for dysfunction of both regions. Importantly, Hrp1 is required to maintain high levels of Cnp1 and low levels of histone H3 and H4 acetylation at the central core region. Hrp1 interacts directly with the centromere in early S-phase when centromeres are replicated, suggesting that Hrp1 plays a direct role in chromatin assembly during DNA replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.