ArticleInfection and immunity2005
Immunological evaluation and cellular location analysis of the TprI antigen of Treponema pallidum subsp. pallidum.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- In-Depth Proteome Coverage of In Vitro-CulturedJournal of proteome research · 2024Article
- Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection.Scientific reports · 2023Article
- Syphilis vaccine: challenges, controversies and opportunities.Frontiers in immunology · 2023Review
- Immunization with Tp0954, an adhesin ofFrontiers in immunology · 2023Article
- Two Potential Syphilis Vaccine Candidates Inhibit Dissemination ofFrontiers in immunology · 2021Article
- A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum.Nature communications · 2017Article
- Vaccine development for syphilis.Expert review of vaccines · 2017Review
- Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry.PLoS neglected tropical diseases · 2016Article
- Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat.Infection and immunity · 2015Article
- Article
- The endemic treponematoses.Clinical microbiology reviews · 2014Review
- Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis.Clinical and vaccine immunology : CVI · 2013Article
- Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.PLoS neglected tropical diseases · 2013Article
- Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.PLoS neglected tropical diseases · 2012Article
- Syphilis: using modern approaches to understand an old disease.The Journal of clinical investigation · 2011Review
- Killing of Treponema denticola by mouse peritoneal macrophages.Journal of dental research · 2010Article
- TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum.Molecular microbiology · 2009Article
- Laboratory diagnosis of syphilis with automated immunoassays.Journal of clinical laboratory analysis · 2009Article
- Molecular studies in Treponema pallidum evolution: toward clarity?PLoS neglected tropical diseases · 2008Article
- On the origin of the treponematoses: a phylogenetic approach.PLoS neglected tropical diseases · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TprI antigen of Treponema pallidum subsp. pallidum is a putative virulence factor predicted to be located in the outer membrane of the syphilis spirochete. In this study, we analyzed the immune response against TprI and its subunits in sera collected both from rabbits experimentally infected with the Nichols strain and from patients with syphilis, showing a different pattern of reactivity toward the antigen in these two groups of samples. The protective ability of recombinant TprI and its hypothetical outer membrane location were also investigated. Although no rabbit was protected after challenge, immunoelectron microscopy results, to be further investigated, were compatible with the outer membrane location of the antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.