ArticleInfection and immunity2005
A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Regulation ofMicrobiology spectrum · 2019Review
- Rot is a key regulator of Staphylococcus aureus biofilm formation.Molecular microbiology · 2015Article
- Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence.Journal of bacteriology · 2015Article
- Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element.Molecular microbiology · 2014Article
- The bicomponent pore-forming leucocidins of Staphylococcus aureus.Microbiology and molecular biology reviews : MMBR · 2014Review
- Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins.Journal of bacteriology · 2012Article
- Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325.Medical microbiology and immunology · 2012Article
- Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.Molecular microbiology · 2012Article
- Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2011Article
- Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.Molecular microbiology · 2011Article
- Peptide signaling in the staphylococci.Chemical reviews · 2011Review
- Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain.FEMS microbiology letters · 2010Article
- Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.PloS one · 2010Article
- Expression of the sarA family of genes in different strains of Staphylococcus aureus.Microbiology (Reading, England) · 2009Article
- SarA is a repressor of hla (alpha-hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.