ArticleInfection and immunity2005
Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Comparative Analysis of Gut Microbiota and Metabolome of Captive Male Malayan Pangolins with Normal and Abnormal Reproduction.Animals : an open access journal from MDPI · 2026Article
- Superior inflammatory response and MASH progression inFrontiers in immunology · 2026Article
- The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies.Microorganisms · 2025Review
- The critical role of interleukin-6 in protection against neurotropic flavivirus infection.Frontiers in cellular and infection microbiology · 2023Article
- Review
- Alterations in the Expression Profile of Serum miR-155, miR-223, miR-17, miR-200a, miR-205, as well as Levels of Interleukin 6, and Prostaglandins during Endometritis in Arabian Mares.Veterinary sciences · 2021Article
- Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.The Journal of infectious diseases · 2021Article
- Antioxidative and Immunomodulatory Potential of the Endemic French Guiana Wild Cocoa "Guiana".Foods (Basel, Switzerland) · 2021Article
- Novel Tyrosine Kinase-Mediated Phosphorylation With Dual Specificity Plays a Key Role in the Modulation ofFrontiers in microbiology · 2021Article
- Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases.Infection and immunity · 2020Article
- The role of interleukin-6 in intracellular signal transduction after chronic β-adrenergic stimulation in mouse myocardium.Archives of medical science : AMS · 2019Article
- Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis.Mediators of inflammation · 2016Article
- Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.The Journal of experimental medicine · 2015Article
- Review
- Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota.Scientific reports · 2014Article
- Rhodomyrtone modulates innate immune responses of THP-1 monocytes to assist in clearing methicillin-resistant Staphylococcus aureus.PloS one · 2014Article
- Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice.PloS one · 2013Article
- Prognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes- induced sepsis.Journal of innate immunity · 2013Article
- Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection.PLoS pathogens · 2011Article
- Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-alpha production in S. pyogenes infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.