ArticleInfection and immunity2005
Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Transcriptomic and proteomic profiling ofFrontiers in cellular and infection microbiology · 2025Article
- Effects of OxyR regulator on oxidative stress, Apx toxin secretion and virulence ofFrontiers in cellular and infection microbiology · 2023Article
- Proteomic Analysis of Stationary Growth Stage Adaptation and Nutritional Deficiency Response ofFrontiers in microbiology · 2020Article
- Pasteurella multocida: Genotypes and Genomics.Microbiology and molecular biology reviews : MMBR · 2019Review
- Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative genomics analysis.Scientific reports · 2016Article
- Article
- The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.Future microbiology · 2013Review
- Ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzae.Infection and immunity · 2013Article
- Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria.Frontiers in cellular and infection microbiology · 2013Review
- Article
- Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential.BMC genomics · 2010Article
- Bioinformatics annotation of the hypothetical proteins found by omics techniques can help to disclose additional virulence factors.Current microbiology · 2009Review
- Host-pathogen interactions of Actinobacillus pleuropneumoniae with porcine lung and tracheal epithelial cells.Infection and immunity · 2009Article
- the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin.PLoS pathogens · 2008Article
- Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.Journal of bacteriology · 2008Article
- Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China.PloS one · 2008Article
- Identification of the Actinobacillus pleuropneumoniae leucine-responsive regulatory protein and its involvement in the regulation of in vivo-induced genes.Infection and immunity · 2007Article
- Use of an Actinobacillus pleuropneumoniae multiple mutant as a vaccine that allows differentiation of vaccinated and infected animals.Infection and immunity · 2006Article
- Iron and fur regulation in Vibrio cholerae and the role of fur in virulence.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.