ArticleInfection and immunity2005
Gamma interferon positively modulates Actinobacillus actinomycetemcomitans-specific RANKL+ CD4+ Th-cell-mediated alveolar bone destruction in vivo.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 77 citations in OpenAlex.
- Maintaining homeostatic control of periodontal bone tissue.Periodontology 2000 · 2021Review
- Transient Expression of IL-17A in Foxp3 Fate-Tracked Cells inFrontiers in immunology · 2020Article
- The function of dendritic cells in modulating the host response.Molecular oral microbiology · 2018Review
- Application of molecular, microbiological, and immunological tests for the diagnosis of bone and joint tuberculosis.Journal of clinical laboratory analysis · 2018Article
- Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis.Journal of dental research · 2016Article
- Emerging roles of immunostimulatory oral bacteria in periodontitis development.Trends in microbiology · 2014Review
- The role of osteoimmunology in periodontal disease.BioMed research international · 2013Review
- Langerhans cells down-regulate inflammation-driven alveolar bone loss.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes.FEMS immunology and medical microbiology · 2011Article
- Review of osteoimmunology and the host response in endodontic and periodontal lesions.Journal of oral microbiology · 2011Article
- Identification of immunological parameters associated with the alveolar bone level in periodontal patients.Journal of periodontal & implant science · 2010Article
- Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes.BMC oral health · 2009Article
- The role of T cells in osteoporosis, an update.International journal of clinical and experimental pathology · 2009Article
- Involvement of SOCS3 in regulation of CD11c+ dendritic cell-derived osteoclastogenesis and severe alveolar bone loss.Infection and immunity · 2009Article
- IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.Journal of clinical periodontology · 2008Review
- IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation.The Journal of clinical investigation · 2007Article
- Oral mucosal dendritic cells and periodontitis: many sides of the same coin with new twists.Periodontology 2000 · 2007Review
- Activated T lymphocytes suppress osteoclastogenesis by diverting early monocyte/macrophage progenitor lineage commitment towards dendritic cell differentiation through down-regulation of receptor activator of nuclear factor-kappaB and c-Fos.Clinical and experimental immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have shown the biological and clinical significance of signaling pathways of osteogenic cytokines RANKL-RANK/OPG in controlling osteoclastogenesis associated with bone pathologies, including rheumatoid arthritis, osteoporosis, and other osteolytic disorders. In contrast to the inhibitory effect of gamma interferon (IFN-gamma) on RANKL-mediated osteoclastogenesis reported recently, alternative new evidence is demonstrated via studies of experimental periodontitis using humanized NOD/SCID and diabetic NOD mice and clinical human T-cell isolates from diseased periodontal tissues, where the presence of increasing IFN-gamma is clearly associated with (i) enhanced Actinobacillus actinomycetemcomitans-specific RANKL-expressing CD4(+) Th cell-mediated alveolar bone loss during the progression of periodontal disease and (ii) a concomitant and significantly increased coexpression of IFN-gamma in RANKL(+) CD4(+) Th cells. Therefore, there are more complex networks in regulating RANKL-RANK/OPG signaling pathways for osteoclastogenesis in vivo than have been suggested to date.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.