ArticleInfection and immunity2005
Diminished monocyte function in microfilaremic patients with lymphatic filariasis and its relationship to altered lymphoproliferative responses.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Immune responses to recombinant Brugia malayi pepsin inhibitor homolog (Bm-33) in patients with human lymphatic filariaisis.Parasitology research · 2011Trial
- Filaria-induced monocyte dysfunction and its reversal following treatment.Infection and immunity · 2006Trial
- Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function.PLoS neglected tropical diseases · 2021Article
- Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence.PLoS neglected tropical diseases · 2015Article
- Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.PLoS pathogens · 2015Article
- Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.PLoS neglected tropical diseases · 2014Article
- Immune responses result in misdiagnosis of Schistosoma japonicum by immunodiagnosis kits in egg-positive patients living in a low schistosomiasis transmission area of China.Parasites & vectors · 2014Article
- Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?Pathogens and disease · 2013Review
- Lymphatic filariasis: perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation.PLoS neglected tropical diseases · 2013Article
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Recombinant Brugia malayi pepsin inhibitor (rBm33) induced monocyte function and absence of apoptotic cell death: an in vitro study.Microbial pathogenesis · 2012Article
- Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro.Microbes and infection · 2012Article
- Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections.Parasitology research · 2012Article
- Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis.Microbes and infection · 2011Article
- Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study.PLoS neglected tropical diseases · 2011Article
- Alternatively activated and immunoregulatory monocytes in human filarial infections.The Journal of infectious diseases · 2009Article
- Lymphoproliferative and cytokine responses to Cryptosporidium parvum in patients coinfected with C. parvum and human immunodeficiency virus.Clinical and vaccine immunology : CVI · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Antigen-specific hyporesponsiveness to filarial antigens is a phenomenon observed in patent infection with lymph-dwelling filarial parasites of humans. This phenomenon has been attributed to a multitude of factors, one of which is altered monocyte function. To examine the role played by monocytes in filarial infection, we assessed the responses of monocytes obtained from normal and filarial parasite-infected individuals to both crude filarial antigen and purified recombinant filarial antigen WbSXP-1 and attempted to relate these to the altered lymphoproliferative responses seen in filarial infection. Monocytes from microfilaremic (MF) patients demonstrated an inability to respond to lipopolysaccharide compared to monocytes from endemic normal persons or from lymphedema patients. Indeed, interleukin 1beta (IL-1beta) production was severely limited, a finding that did not extend to monocyte responses to filarial antigens. Serum from MF patients reduced adherence and spreading of normal monocytes, a finding not seen with serum from the other clinical groups. Interestingly, there was a significant correlation between the production of IL-1beta and adherence. Moreover, the levels of spontaneous production of IL-1beta correlated with high levels of spontaneous secretion of IL-10. The effects observed were not a result of diminished viability or alteration in the expression of the cell surface markers CD14 and HLA-DR. These data suggest that monocyte function is dampened in MF patients, a finding which could alter lymphoproliferative responses during patent infection.
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