ArticleInfection and immunity2005
Inactivation of Streptococcus gordonii SspAB alters expression of multiple adhesin genes.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Identification of a conserved GNAT-family lysine acetyltransferase inJournal of bacteriology · 2026Article
- Assessment of Oral Hygiene Practices, Adjunctive Cleaning Methods, and Their Impact on Plaque and Gingival Indices Among Young Adults in Urban and Rural Settings in Romania.Healthcare (Basel, Switzerland) · 2025Article
- Streptococcus gordonii Poised for Glycan Feeding through a MUC5B-Discriminating, Lipoteichoic Acid-Mediated Outside-In Signaling Circuit.Journal of bacteriology · 2022Article
- Uncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle.Journal of bacteriology · 2020Article
- Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability.BMC microbiology · 2020Article
- Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis.mSphere · 2019Article
- An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.Science signaling · 2019Article
- Coassociation between Group B Streptococcus and Candida albicans Promotes Interactions with Vaginal Epithelium.Infection and immunity · 2018Article
- Getting to the heart of the matter: Role of Streptococcus mutans adhesin Cnm in systemic disease.Virulence · 2017Article
- Article
- N-Acetyl-l-cysteine effects on multi-species oral biofilm formation and bacterial ecology.Letters in applied microbiology · 2016Article
- The oral microbiome and the immunobiology of periodontal disease and caries.Immunology letters · 2014Review
- Functional analysis of paralogous thiol-disulfide oxidoreductases in Streptococcus gordonii.The Journal of biological chemistry · 2013Article
- CcpA regulates biofilm formation and competence in Streptococcus gordonii.Molecular oral microbiology · 2012Article
- Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation.Molecular microbiology · 2011Article
- New cell surface protein involved in biofilm formation by Streptococcus parasanguinis.Infection and immunity · 2011Article
- Mechanism of adhesion maintenance by methionine sulphoxide reductase in Streptococcus gordonii.Molecular microbiology · 2011Article
- Adhesion determinants of the Streptococcus species.Microbial biotechnology · 2010Review
- Deleted in malignant brain tumors-1 protein (DMBT1): a pattern recognition receptor with multiple binding sites.International journal of molecular sciences · 2010Review
- Characterization of hydrogen peroxide-induced DNA release by Streptococcus sanguinis and Streptococcus gordonii.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
SspA and SspB (antigen I/II family proteins) can bind Streptococcus gordonii to other oral bacteria and also to salivary agglutinin glycoprotein, a constituent of the salivary film or pellicle that coats the tooth. To learn if SspA and SspB are essential for adhesion and initial biofilm formation on teeth, S. gordonii DL1 was incubated with saliva-coated hydroxyapatite (sHA) for 2 h in Todd-Hewitt broth with 20% saliva to develop initial biofilms. Sessile cells attached to sHA, surrounding planktonic cells, and free-growing cells were recovered separately. Free-growing cells expressed more sspA-specific mRNA and sspB-specific mRNA than sessile cells. Free-growing cells expressed the same levels of sspA and sspB as planktonic cells. Surprisingly, an SspA(-) SspB(-) mutant strain showed 2.2-fold greater biofilm formation on sHA than wild-type S. gordonii DL1. To explain this observation, we tested the hypothesis that inactivation of sspA and sspB genes altered the expression of other adhesin genes during initial biofilm formation in vitro. When compared to wild-type cells, expression of scaA and abpB was significantly up-regulated in the SspA(-) SspB(-) strain in sessile, planktonic, and free-growing cells. Consistent with this finding, ScaA antigen was also overexpressed in planktonic and free-growing SspA(-) SspB(-) cells compared to the wild type. SspA/B adhesins, therefore, were strongly suggested to be involved in the regulation of multiple adhesin genes.
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